Results 71 to 80 of about 112,346 (350)
The Oncologist, EarlyView., 2021 Abstract Background LIBRETTO‐001 is an ongoing, global, open‐label, phase I/II study of selpercatinib in patients with advanced or metastatic solid tumors. We report interim patient‐reported outcomes in patients with RET fusion–positive non‐small cell lung cancer (NSCLC).
Anna Minchom +11 more
wiley +1 more source
Comparison of three with six regions of interest analyses in patients with idiopathic constipation undertaking colon transit scintigraphy using 67Ga-citrate [PDF]
, 2013 OBJECTIVE AND INTRODUCTION: Preparation of data from 6 geometric regions of interest in the colon is time consuming, and can become impractical in the environment of busy Nuclear Medicine Departments.
Asli, I.N. +5 more
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Treatment of irritable bowel syndrome [PDF]
, 2005 Irritable bowel syndrome is characterised by diverse symptoms including abdominal pain, altered bowel function (increased bowel frequency, constipation), bloating, abdominal distension, the sensation of incomplete evacuation, and the increased passage of
Farthing, Michael
core +1 more source
Advanced NanoBiomed Research, EarlyView.This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari +5 more
wiley +1 more source
The Oncologist, EarlyView., 2021 Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth +10 more
wiley +1 more source
Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation [PDF]
, 2005 Aim: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls. Methods: Constipation was diagnosed by Rome II criteria.
Chan, AOO +9 more
core +2 more sources
British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić +7 more
wiley +1 more source
Polyethylene glycol and prevalence of colorectal adenomas : Population-based study of 1165 patients undergoing colonoscopy [PDF]
, 2006 Background and aim — Dietary polyethylene glycol (PEG) is extraordinarily potent in the chemoprevention of experimental colon carcinogenesis. PEG is used to treat constipation in France and in the USA. French laxatives include Forlax® (PEG4000), Movicol®
Barbieux, Jean-Pierre +7 more
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Exploring the genetics of irritable bowel syndrome: A GWA study in the general population and replication in multinational case-control cohorts [PDF]
, 2014 OBJECTIVE: IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies.
Agreus, Lars +43 more
core +1 more source
Functional Constipation in Children
, 2016 Childhood constipation is a common pediatric healthcare problem. The diagnosis is based on history and physical examination, in accordance with the pediatric diagnostic Rome III criteria. Additional investigations are only indicated if the diagnosis is not clear or in order to rule out an underlying organic disease.
Koppen, Ilan J. N., Benninga, Marc A.
openaire +2 more sources