Results 51 to 60 of about 63,859 (253)

Slow transit constipation: clinical and aetiological studies.

, 2000
PhDConstipation is the second most commonly self-reported gastrointestinal symptom. On the basis of anorectal physiological investigations and colonic transit studies, a subgroup of patients with several intractable symptoms, but without organic ...
Knowles, Charles H
core  

L-Arabinose Alleviates Functional Constipation in Mice by Regulating Gut Microbiota and Metabolites

Functional constipation ranks among the most common disorders impacting human health, which is manifested by difficulty in defecation and a complex etiology.
Huixuan Dong, Xiaolin Zhang, Yushan Du, Penghui Yang, Jing Meng, Chaoqun Hu, Shiji Li, Wenna Ji, Ke Liu, Xinran Li, Wenjie Sui, Fengya Cui   +11 more
core   +1 more source

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Cynthia E. Kartman, Peter Fischer, Luna Sun, Píndaro Martínez‐Osuna, Andris Kronbergs, Purvi Prajapati, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

Childhood functional constipation : Parents' everyday life experiences

, 2022
Background: Functional constipation is the most common chronic disorder in childhood with a great impact on family life. Treatment focuses on the behavioural nature of the disorder with toilet training and laxatives, with the goal of daily stool passage ...
Flankegård, Gunilla
core   +1 more source

Associations Between Comorbidities, Developmental Status, and Disease Severity in Children With Autism Spectrum Disorder: A Multicenter Cross‐Sectional Study in China

Autism Research, EarlyView.
ABSTRACT Children with autism spectrum disorder (ASD) frequently present with co‐occurring conditions that can influence autism symptom severity and complicate clinical management. However, studies with clinician‐confirmed diagnoses in non‐Western populations remain limited.
Dizhou Pang, Guiqin Duan, Qing Shang, Huichun Zhang, Binbin Wang, Huaili Ding, Huihui Kang, Yue Zhao, Yuxia Lu, Gai Tian, Li Zhang, Wu Jiang, Ganyu Wang, Cailing Liang, Lingling Zhang, Bingbing Li, Zhenghua Li, Chunlan Song, Yanyan Yang, Yazhe Wang, Kaichen Yue, Yongbin Lang, Jiatian Liu, Xiaoli Zhang, Yiran Xu, Changlian Zhu   +25 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Response to a behavioural treatment, biofeedback, in constipated patients is associated with improved gut transit and autonomic innervation

, 2001
Background: Although behavioural treatment (biofeedback) successfully treats the pelvic floor abnormalities in patients with idiopathic constipation, many patients also normalise their impaired bowel frequency.
Emmanuel, A.V., Kamm, M.A.
core  

Normalization of Gastrointestinal Symptoms in Adults With Constipation With Daily Green Kiwifruit Consumption: Protocol for an Open-Label Intervention Study

Background:Irritable bowel syndrome with constipation (IBS-C) and functional constipation (FC) have significant personal, health care, and social impacts, affecting patients’ quality of life. Treatment of these conditions is challenging.
Maggo, Jasjot, Foster, Meika, Spiller, Robin, Günther, Catrin S, Milan, Amber, Bayer, Simone Birgit, Gasser, Olivier, Tang, Jeffery, Ng, Hwei Min, Cooney, Janine M, Mullaney, Jane, Wall, Catherine L, Marciani, Luca, Trower, Tania, Frampton, Chris, Fraser, Karl, Conner, Tamlin, McNabb, Warren C, Hoad, Caroline L, Cabrera, Diana, Roy, Nicole C, Gearry, Richard B   +21 more
core   +1 more source

Pediatric Functional Constipation Gastrointestinal Symptom Profile Compared With Healthy Controls

, 2015
Patient-reported outcomes are necessary to evaluate the gastrointestinal symptom profile of patients with functional constipation. Study objectives were to compare the gastrointestinal symptom profile of pediatric patients with functional constipation ...
Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module Testing Study Consortium, Saps, Miguel, Self, Mariella M, Pohl, John F, Nurko, Samuel, Shulman, Robert J, Varni, James W, Bendo, Cristiane B, Vaughan Dark, Chelsea   +8 more
core   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source