Results 71 to 80 of about 65,633 (254)

Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care

Epilepsia Open, EarlyView.
Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley, Peter Widdess‐Walsh, Christine Linehan, Danielle M. Andrade, Norman Delanty, Patrick B. Moloney   +5 more
wiley   +1 more source

Patient‐Reported Outcomes with Selpercatinib Among Patients with RET Fusion–Positive Non‐Small Cell Lung Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background LIBRETTO‐001 is an ongoing, global, open‐label, phase I/II study of selpercatinib in patients with advanced or metastatic solid tumors. We report interim patient‐reported outcomes in patients with RET fusion–positive non‐small cell lung cancer (NSCLC).
Anna Minchom, Aaron C. Tan, Erminia Massarelli, Vivek Subbiah, Valentina Boni, Bruce Robinson, Lori J. Wirth, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Caroline E. McCoach   +11 more
wiley   +1 more source

Exploring medical food supplementation as an adjunct strategy for microbiota restoration and seizure reduction in CDKL5 deficiency disorder

Epilepsia Open, EarlyView.
Abstract Objectives CDKL5 deficiency disorder (CDD) is a developmental and epileptic encephalopathy characterized by early‐onset, treatment‐resistant seizures and severe neurodevelopmental impairment. Increasing evidence suggests that alterations in the gut–brain axis may contribute to disease pathophysiology, raising interest in microbiota‐targeted ...
Elisa Borghi, Matteo Domenico Marsiglia, Francesca Triva, Emerenziana Ottaviano, Ilaria Viganò, Miriam Nella Savini, Valentino Costabile, Aglaia Vignoli   +7 more
wiley   +1 more source

Patient‐Reported Outcomes with Selpercatinib Treatment Among Patients with RET‐Mutant Medullary Thyroid Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth, Bruce Robinson, Valentina Boni, Daniel S.W. Tan, Caroline McCoach, Erminia Massarelli, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Vivek Subbiah   +10 more
wiley   +1 more source

Seoul Consensus on Clinical Practice Guidelines for Functional Constipation

The Korean Journal of Gastroenterology
Chronic constipation is one of the most common digestive diseases encountered in clinical practice. Constipation manifests as a variety of symptoms, such as infrequent bowel movements, hard stools, feeling of incomplete evacuation, straining at ...
Kyung Ho Song, Young Sin Cho, Jeong Eun Shin, Hye-Kyung Jung, Seon-Young Park, Seung Joo Kang, Jung-Wook Kim, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea, Hyun Chul Lim, Hee Sun Park, Seong-Jung Kim, Ra Ri Cha, Ki Bae Bang, Chang Seok Bang, Sung Kyun Yim, Seung-Bum Ryoo, Bong Hyeon Kye, Woong Bae Ji, Miyoung Choi, In-Kyung Sung, Suck Chei Choi   +20 more
doaj   +1 more source

Maladaptive Weight‐Related Compensatory Behaviours Among Individuals Undergoing Metabolic and Bariatric Surgery

European Eating Disorders Review, EarlyView.
ABSTRACT Introduction Little is known about maladaptive, weight‐related compensatory behaviours (CB) among individuals undergoing metabolic and bariatric surgery (MBS). This brief report examined CB typically associated with restrictive types of eating disorders, including fasting (≥ 8 hours), self‐induced vomiting, and misuse of laxatives and ...
Deborah Lynn Reas, Selma Øverland Lie, Tom Mala, Ingela Lundin Kvalem   +3 more
wiley   +1 more source

THE RELATIONSHIP BETWEEN MENTAL HEALTH AND FUNCTIONAL CONSTIPATION AMONG ADOLESCENTS

Jurnal Kedokteran dan Kesehatan
Constipation is a common digestive problem that is divided into primary (functional) and secondary. Functional constipation is diagnosed using the Rome IV criteria, which include symptoms such as straining, hard stools, incomplete defecation, and a ...
Evi Rokhayati, Adila Putri Istiqomah, Tri Oktaviyantini, Fadhilah Tia Nur   +3 more
doaj   +1 more source

Profiling of Dietary Fiber From Pumpkin (Cucurbita moschata) Seed Hulls Pertaining to Monosaccharide Composition, Structural, Thermal, and Functional Properties

Food Chemistry International, EarlyView.
Dietary fiber (soluble/insoluble) was recovered from pumpkin seed hulls using hydrothermal extraction. Process parameters were optimized, and a comprehensive profiling of recovered fiber fractions was performed. ABSTRACT Insoluble (IDF) and soluble dietary fiber (SDF) were recovered from pumpkin seed hulls (PSHs) using hydrothermal treatment ...
Rishabh Thakur, H. K. Sharma
wiley   +1 more source

Valorization of Citrus Waste for Recovery of Nutritional and Bioactive Compounds: A Comprehensive Review

Future Postharvest and Food, EarlyView.
The various citrus wastes, including the citrus fruit peels, pulp remaining after extraction of juice, and seeds, are the sources of bioactive compounds. The waste parts of oranges, lemons, limes, grapefruits, and mandarins contain the bioactive compounds, flavonoids, ascorbic acid, essential oils, and carotenoids.
Monika, Rhythm Kalsi, Jasleen Kaur Bhasin, Rafeeya Shams, Kshirod Kumar Dash   +4 more
wiley   +1 more source

Identifying Avoidable Emergency Department Visits and the Potential Role of Community Health Centers in Northern Italy: A Retrospective Observational Study

Health Care Science, EarlyView.
Using data from an Italian emergency department (ED), ED visits preventable through integrated community care models (community health centers) were identified. ED visits were classified based on presenting symptoms, comorbidities, medication use, and age.
Silvia Caristia, Isabella Santomauro, Erika Bassi, Laura Ferraris, Alberto Dal Molin, Fabrizio Faggiano   +5 more
wiley   +1 more source