Results 81 to 90 of about 110,424 (352)

Experience of application of modern laxatives at treatment of functional constipation at adults

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2010
Aim of investigation. To estimate efficacy and tolerability of Forlax® in non-interventional observation study as laxative agent at short-term constipation for achievement of one-time laxative effect and at long course treatment of functional chronic ...
Ye. K. Baranskaya
doaj  

Exploring the genetics of irritable bowel syndrome: A GWA study in the general population and replication in multinational case-control cohorts [PDF]

, 2014
OBJECTIVE: IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies.
Agreus, Lars, Andreasson, Anna, Assadi, Ghazaleh, Barbara, Giovanni, Barbaro, Raffaella, Bellini, Massimo, Blandizzi, Corrado, Boeckxstaens, Guy, Bresso, Francesca, Burwinkel, Barbara, Camilleri, Michael, Colucci, Rocchina Lucia, D'Amato, Mauro, Daly, Mark J., Dlugosz, Aldona, Ek, Weronica E., Gambaccini, Dario, Gazouli, Maria, Holliday, Elizabeth G., Houghton, Lesley, Karamanolis, George, Karling, Pontus, Li, Ling, Lindberg, Greger, Magnusson, Patrik, Marchi, Santino, Niesler, Beate, Ohlsson, Bodil, Papadaki, Evangelia, Pedersen, Nancy L., Rafter, Joseph, Rappold, Gudrun, Reznichenko, Anna, Ripke, Stephan, Rivera, Natalia V., Schmidt, Peter T., Simren, Magnus, Stanghellini, Vincenzo, Surowy, Harald, Talley, Nicholas J., Tornblom, Hans, Walter, Susanna, Wouters, Mira M., Zucchelli, Marco   +43 more
core   +1 more source

Patient‐Reported Outcomes with Selpercatinib Among Patients with RET Fusion–Positive Non‐Small Cell Lung Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background LIBRETTO‐001 is an ongoing, global, open‐label, phase I/II study of selpercatinib in patients with advanced or metastatic solid tumors. We report interim patient‐reported outcomes in patients with RET fusion–positive non‐small cell lung cancer (NSCLC).
Anna Minchom, Aaron C. Tan, Erminia Massarelli, Vivek Subbiah, Valentina Boni, Bruce Robinson, Lori J. Wirth, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Caroline E. McCoach   +11 more
wiley   +1 more source

Tapentadol extended release for the management of chronic neck pain [PDF]

, 2017
BACKGROUND: The role of opioids in the management of chronic neck pain is still poorly investigated. No data are available on tapentadol extended release (ER).
Coluzzi, Flaminia
core   +1 more source

Relative Bioavailability, Food Effect, and Bioequivalence Studies to Assess a New Zanubrutinib 160‐mg Tablet: Results From 2 Phase 1 Studies in Healthy Volunteers

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Zanubrutinib is a next‐generation Bruton tyrosine kinase inhibitor approved for treating B‐cell malignancies. Two phase 1 studies evaluated a new 160‐mg zanubrutinib tablet versus 80‐mg capsules. In study BGB‐3111‐115 (n = 43), a randomized 3‐period crossover trial, relative bioavailability and food effects were assessed.
Bilal Tariq, Chester Lin, Vaibhav Mundra, Yang Gao, Dan Zhang, Ying C. Ou   +5 more
wiley   +1 more source

Patient‐Reported Outcomes with Selpercatinib Treatment Among Patients with RET‐Mutant Medullary Thyroid Cancer in the Phase I/II LIBRETTO‐001 Trial

The Oncologist, EarlyView., 2021
Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth, Bruce Robinson, Valentina Boni, Daniel S.W. Tan, Caroline McCoach, Erminia Massarelli, Lisa M. Hess, Min‐Hua Jen, Jennifer Kherani, Elizabeth Olek, Vivek Subbiah   +10 more
wiley   +1 more source

Guillain-Barre syndrome (GBS) [PDF]

, 2013
A 57-year-old Caucasian gentleman presented with bilateral progressive distal upper limb paraesthesiae, which he described as a feeling of “heaviness” followed by distal lower limb and mild tongue parasthaesia.
Grima, Maria Angela
core  

The Prevalence and Burden of Avoidant/Restrictive Food Intake Disorder (ARFID) Symptoms in the Adult General Population of the UK and USA

International Journal of Eating Disorders, EarlyView.
ABSTRACT Introduction Avoidant/Restrictive Food Intake Disorder (ARFID) is a feeding and eating disorder characterized by avoidant/restrictive eating behaviors that lead to medical and/or functional impairments. While ARFID is increasingly recognized within pediatric populations and specialist clinics, data on its prevalence and burden within the adult
Grace Brownlow, Rosie Flack, Helen Burton‐Murray, Olafur Palsson, Imran Aziz   +4 more
wiley   +1 more source

Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice [PDF]

, 2005
BACKGROUND: Lantana camara L. (Verbenaceae), a widely growing shrub which is toxic to some animal species, has been used in the traditional medicine for treating many ailments.
Ojha, Sudarshan, Sagar, Lenika, Sehgal, Rajesh   +2 more
core   +2 more sources

Impact of breastfeeding during infancy on functional constipation at 3 years of age: the Japan Environment and Children’s Study

International Breastfeeding Journal, 2023
Background There is a lack of large, nationwide, birth cohort studies in Japan that examine the relationships of initial feeding habits and breastfeeding period duration with offspring functional constipation at 3 years of age.
Noriko Motoki, Yuji Inaba, Hirokazu Toubou, Kohei Hasegawa, Takumi Shibazaki, Teruomi Tsukahara, Tetsuo Nomiyama, the Japan Environment and Children’s Study (JECS) Group   +7 more
doaj   +1 more source