Results 21 to 30 of about 480 (227)
Belief functions contextual discounting and canonical decompositions
International Journal of Approximate Reasoning, 2012 In this article, the contextual discounting of a belief function, a classical discounting generalization, is extended and its particular link with the canonical disjunctive decomposition is highlighted. A general family of correction mechanisms allowing one to weaken the information provided by a source is then introduced, as well as the dual of this ...
David Mercier +2 more
openaire +2 more sources
Comparative Analysis of Space Syntax and PPS Matrix Methods in Measuring Spatial Quality (Case Study: Bazar-e Tabriz) [PDF]
برنامهریزی توسعه شهری و منطقهایThe challenge of determining the most appropriate method for spatial analysis has long captivated the attention of researchers. Many spatial studies rely solely on either quantitative or qualitative research methods and techniques, yielding insights that
seyyed mohammadmahdi Hosseinikia +3 more
doaj +1 more source
Functional Neuroanatomy of Contextual Acquisition of Concrete and Abstract Words [PDF]
Journal of Cognitive Neuroscience, 2009 Abstract The meaning of a novel word can be acquired by extracting it from linguistic context. Here we simulated word learning of new words associated to concrete and abstract concepts in a variant of the human simulation paradigm that provided linguistic context information in order to characterize the brain systems involved.
Anna Mestres-Missé +2 more
openaire +5 more sources
Category of «Context» and Contextual Approach in Psychology [PDF]
Psychology in Russia: State of Art, 2012 The article contains a brief review of the concept «context» which is gaining itsplace among the key concepts in modern theoretical and empirical psychology.
Vitaly G. Kalashnikov Sholohov +1 more
doaj
Contextual functions of antigen‐presenting cells in the gastrointestinal tract [PDF]
Immunological Reviews, 2014 SummaryThe immune system of the gastrointestinal tract must be tightly regulated to limit pathologic responses toward innocuous antigens while simultaneously allowing for rapid development of effector responses against invading pathogens. Highly specialized antigen‐presenting cell (APC) subsets present in the gut play a dominant role in balancing these
Grainger, John R.; id_orcid 0000-0002-4052-5923 +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source