Results 91 to 100 of about 29,887,370 (259)

Modelling the Impact of Community Well-Being on Individual Well-Being. An Empirical Appraisal of Alternative Approaches

Journal of Modern Science
Objectives Measuring complex multidimensional phenomena such as the community well-being over time provides several challenges. The main difficulties are due to changes of well-being – at both group/community level and at the individual/household level.
Włodzimierz Okrasa
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

FILTRATED COMMON FUNCTIONAL PRINCIPAL COMPONENT ANALYSIS OF MULTIGROUP FUNCTIONAL DATA

Local field potentials (LFPs) are signals that measure electrical activities in localized cortical regions and are collected from multiple tetrodes implanted across a patch on the surface of cortex.
Jiao, Shuhao, Ombao, Hernando, Frostig, Ron   +2 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

DEPTH-BASED CLASSIFICATION FOR FUNCTIONAL DATA [PDF]

Classification is an important task when data are curves. Recently, the notion of statistical depth has been extended to deal with functional observations.
Juan Romo, Sara Lopez-Pintado
core  

On the concept of depth for functional data [PDF]

, 2006
The statistical analysis of functional data is a growing need in many research areas. We propose a new depth notion for functional observations based on the graphic representation of the curves. Given a collection of functions, it allows to establish the
Sara López-Pintado, Juan Romo, Romo, Juan, López Pintado, Sara   +3 more
core   +1 more source

A Novel Hybrid Algorithm to Forecast Functional Time Series Based on Pattern Sequence Similarity with Application to Electricity Demand

Energies, 2018
The forecasting of future values is a very challenging task. In almost all scientific disciplines, the analysis of time series provides useful information and even economic benefits.
Francisco Martínez-Álvarez, Amandine Schmutz, Gualberto Asencio-Cortés, Julien Jacques   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

functional data

, 2020
Functional data analysis (FDA) is a branch of statistics that analyzes data providing information about curves, surfaces or anything else varying over a continuum. In its most general form, under an FDA framework each sample element is considered to be a
Yu, P (via Mendeley Data)
core   +1 more source