Results 231 to 240 of about 3,633,355 (289)
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Unraveling time-varying causal effects of multiple exposures: integrating Functional Data Analysis with Multivariable Mendelian Randomization [PDF]
Nicole Fontana +4 more
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Functional analysis of glaucoma data
Statistics in Medicine, 2013We refer glaucoma to a category of eye disorders often associated with a dangerous buildup of intraocular pressure (IOP), which can damage the eyes’ optic nerve that transmits visual information to the brain. Because IOP changes over time, it is a function of time, and it is an advantage that we analyze the phenomenon using functional data analysis. In
Hosseini-Nasab, Mohammad +1 more
openaire +3 more sources
2001
Most statistical analyses involve one or more observations taken on each of a number of individuals in a sample, with the aim of making inferences about the general population from which the sample is drawn. In an increasing number of fields, these observations are curves or images.
Silverman, BW, Ramsay, JO
openaire +1 more source
Most statistical analyses involve one or more observations taken on each of a number of individuals in a sample, with the aim of making inferences about the general population from which the sample is drawn. In an increasing number of fields, these observations are curves or images.
Silverman, BW, Ramsay, JO
openaire +1 more source
Functional Analysis of Metabolomics Data
2016Metabolomics aims at characterizing the repertory of small chemical compounds in a biological sample. As it becomes more massive and larger sets of compounds are detected, a functional analysis is required to convert these raw lists of compounds into biological knowledge.
Mónica, Chagoyen +2 more
openaire +2 more sources