Results 161 to 170 of about 1,541,674 (284)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Evaluation of the clinical frailty scale for predicting mortality or functional dependence at ICU discharge: A cohort study. [PDF]

Sci Rep
Kozesinski-Nakatani AC, Bernardelli RS, Vieira JCF, Martins-Junior MJ, Tiba MN, Barros VS, Tiba T, Konzen BL, Janiscki K, Réa-Neto Á, de Lima Moser AD.   +10 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Unmet needs and functional dependence predict burnout, health outcomes, and institutionalization desire among informal caregivers: a multi-regional path analysis study. [PDF]

BMC Nurs
Alhalal E, Salami S, Alenazi AA, Alqethami A, Albaqami AS, Almutairi S.   +5 more
europepmc   +1 more source

Quality of life related to functional dependence, family functioning and social support in older adults. [PDF]

Rev Esc Enferm USP, 2022
Alonso MAM, Barajas MES, Ordóñez JAG, Ávila Alpirez H, Fhon JRS, Duran-Badillo T.   +5 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Combined Effects of Depression, Fatigue and Cardiovascular Dysfunction on Functional Dependence Over Seven Years in Early Parkinson's Disease. [PDF]

Mov Disord Clin Pract
Stewart CB, Sathyanarayana S, Foster VK, Iredale R, Galley D, Pasquini J, Anderson KN, Pavese N, Ledingham D.   +8 more
europepmc   +1 more source

[Functional dependence and support for the older persons in Mexico, 2001-2026Dependência funcional e apoio em idosos no México, 2001-2026]. [PDF]

Rev Panam Salud Publica, 2021
González-González C, Cafagna G, Hernández Ruiz MDC, Ibarrarán P, Stampini M.   +4 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Disparities in functional dependence and population aging in Latin America. [PDF]

Rev Panam Salud Publica
García Chanes RE, Casasola Espinosa BA, Gutiérrez Robledo LM.   +2 more
europepmc   +1 more source