Results 91 to 100 of about 3,269,321 (296)

Differing temperature dependencies of functional homologs zebrafish Abcb4 and human ABCB1

open access: yesFrontiers in Pharmacology
The ATP binding cassette (ABC) transporters human ABCB1 and zebrafish (Danio rerio) Abcb4 are functionally homologous multixenobiotic/multidrug (MXR/MDR) efflux transporters that confer the efflux of a broad range of diverse chemical compounds from the ...
Till Luckenbach   +1 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Universal Dependencies 2.2

open access: yes, 2018
Universal Dependencies is a project that seeks to develop cross-linguistically consistent treebank annotation for many languages, with the goal of facilitating multilingual parser development, cross-lingual learning, and parsing research from a language ...
Regnault, Mathilde   +711 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Treebank-based acquisition of a Chinese lexical-functional grammar [PDF]

open access: yes, 2004
Scaling wide-coverage, constraint-based grammars such as Lexical-Functional Grammars (LFG) (Kaplan and Bresnan, 1982; Bresnan, 2001) or Head-Driven Phrase Structure Grammars (HPSG) (Pollard and Sag, 1994) from fragments to naturally occurring ...
O'Donovan, Ruth   +7 more
core   +2 more sources

Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes. [PDF]

open access: yesCell Rep, 2021
McMurray HR   +8 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

From surface dependencies towards deeper semantic representations [Semantic representations] [PDF]

open access: yes, 2006
In the past, a divide could be seen between ’deep’ parsers on the one hand, which construct a semantic representation out of their input, but usually have significant coverage problems, and more robust parsers on the other hand, which are usually based ...
Zinsmeister, Heike, Versley, Yannick
core  

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