Results 91 to 100 of about 5,936,360 (329)
Comput. Biol. Medicine, 2015 Functional dependencies (FDs) typically represent associations over facts stored by a database, such as "patients with the same symptom get the same therapy." In more recent years, some extensions have been introduced to represent both temporal ...
Combi Carlo +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
From Lexical Functional Grammar to enhanced Universal Dependencies
Language Resources and Evaluation, 2018 The paper describes the conversion of an LFG treebank of Polish into enhanced Universal Dependencies, and—more generally—identifies the kinds of information lost in translation from LFG to UD.
A. Przepiórkowski, Agnieszka Patejuk
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
GENERAL PRINCIPLES OF CONSTRUCTION OF SYSTEMS OF INDEXATION OF ELEMENTS OF FINITE SETS
Вестник Дагестанского государственного технического университета: Технические науки, 2019 Objectives Definition of general principles for constructing indexing systems for elements of finite sets.Method. Building a model of the indexing process. Definition of general rules for assigning attributes - indices to elements of sets.Result.
I. P. Kadiev
doaj +1 more source
Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes. [PDF]
Cell Rep, 2021 McMurray HR +8 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Differing temperature dependencies of functional homologs zebrafish Abcb4 and human ABCB1
Frontiers in PharmacologyThe ATP binding cassette (ABC) transporters human ABCB1 and zebrafish (Danio rerio) Abcb4 are functionally homologous multixenobiotic/multidrug (MXR/MDR) efflux transporters that confer the efflux of a broad range of diverse chemical compounds from the ...
Till Luckenbach +1 more
doaj +1 more source