Exploiting functional dependencies in declarative problem specifications [PDF]
, 2007 In this paper we tackle the issue of the automatic recognition of functional dependencies among guessed predicates in constraint problem specifications.
Mancini, Toni +3 more
core +1 more source
Differing temperature dependencies of functional homologs zebrafish Abcb4 and human ABCB1
Frontiers in PharmacologyThe ATP binding cassette (ABC) transporters human ABCB1 and zebrafish (Danio rerio) Abcb4 are functionally homologous multixenobiotic/multidrug (MXR/MDR) efflux transporters that confer the efflux of a broad range of diverse chemical compounds from the ...
Till Luckenbach +1 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes. [PDF]
Cell Rep, 2021 McMurray HR +8 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Weak functional dependencies on trees with restructuring [PDF]
, 2011 We present an axiomatisation for weak functional dependencies, i.e. disjunctions of functional dependencies, in the presence of several constructors for complex values. The investigated constructors capture records, sets, multisets, lists, disjoint union
Sali Attila, Schewe Klaus-Dieter
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
GENERAL PRINCIPLES OF CONSTRUCTION OF SYSTEMS OF INDEXATION OF ELEMENTS OF FINITE SETS
Вестник Дагестанского государственного технического университета: Технические науки, 2019 Objectives Definition of general principles for constructing indexing systems for elements of finite sets.Method. Building a model of the indexing process. Definition of general rules for assigning attributes - indices to elements of sets.Result.
I. P. Kadiev
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Restoring confluence for functional dependencies [PDF]
, 2008 Functional dependencies provide for a relational specification of user-programmable type improvement connected to type class instances. On the other hand, the more recent type families (also known as type functions) equip the programmer with a functional
Sulzmann, Martin, Schrijvers, Tom
core +1 more source