Results 221 to 230 of about 273,540 (290)

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Integrative Multi-Omics Analyses Reveal Mechanisms of Resistance to Hsp90β-Selective Inhibition. [PDF]

Cancers (Basel)
Mersich I, Anik E, Ali A, Blagg BSJ.
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Older people in Sweden increasingly enter long-term care with extensive care needs-a register study of first-time users based on the SNAC Stockholm Eldercare study. [PDF]

Eur J Ageing
Meinow B, Goliath I, Wallcook S, Flink M, Siljehag PA, Klinga C, Strehlenert H, von Berens Å.   +7 more
europepmc   +1 more source

Serial dependencies and overt attention shifts. [PDF]

J Vis
Tyralla S, Zimmermann E.
europepmc   +1 more source

DFL-MHC: MHC identification model based on dual-stage training and multi-view feature fusion. [PDF]

Front Genet
Li Y, Lin Y, Chen D.
europepmc   +1 more source

Predicting genetic evolution of viruses to identify suitable vaccines using artificial intelligence. [PDF]

Sci Rep
Shahin OR, Ibrahim MN, Alanazi A, Alharithi FS, Alruwaili Y, Alzahrani AA, El Azab EF.   +6 more
europepmc   +1 more source

A temporal convolutional network approach for gait-based fall risk prediction to support safe sport participation in older adults. [PDF]

MethodsX
Askhatova A, Sharipov U, Kasenov S, Kassenov K, Kenzhin Z, Kuangaliyeva T, Turzhanova D, Jamwal PK.   +7 more
europepmc   +1 more source