Results 51 to 60 of about 630,437 (290)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Human Gene Functional Network-Informed Prediction of HIV-1 Host Dependency Factors

mSystems, 2020
Human immunodeficiency virus type 1 (HIV-1) depends on a class of host proteins called host dependency factors (HDFs) to facilitate its infection. So far experimental efforts have detected a certain number of HDFs, but the gene inventory of HIV-1 HDFs ...
Chen Fu, Shiping Yang, Xiaodi Yang, Xianyi Lian, Yan Huang, Xiaobao Dong, Ziding Zhang   +6 more
doaj   +1 more source

Arabic parsing using grammar transforms [PDF]

, 2010
We investigate Arabic Context Free Grammar parsing with dependency annotation comparing lexicalised and unlexicalised parsers. We study how morphosyntactic as well as function tag information percolation in the form of grammar transforms (Johnson, 1998 ...
Tounsi, Lamia, van Genabith, Josef
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

LFG without C-structures [PDF]

, 2010
We explore the use of two dependency parsers, Malt and MST, in a Lexical Functional Grammar parsing pipeline. We compare this to the traditional LFG parsing pipeline which uses constituency parsers.
Cahill, Aoife, Cetinoglu, Ozlem, Foster, Jennifer, Hogan, Deirdre, Nivre, Joakim, van Genabith, Josef   +5 more
core   +1 more source

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. [PDF]

, 2018
Functional redundancy shared by paralog genes may afford protection against genetic perturbations, but it can also result in genetic vulnerabilities due to mutual interdependency1-5.
Berger, Ashton C, Bhatia, Sangeeta N, Buss, Colin G, Carr, Steven A, Cherniack, Andrew D, Choi, Peter S, Hahn, William C, Krill-Burger, John M, Lage, Kasper, Malolepsza, Edyta, Meyerson, Matthew, Nogueira, Marina F, Pedamallu, Chandra Sekhar, Schenone, Monica, Shih, Juliann, Strathdee, Craig A, Tamayo, Pablo, Tanenbaum, Benjamin, Taylor, Alison M, Tsherniak, Aviad, Vazquez, Francisca, Viswanathan, Srinivas R, Wawer, Mathias J   +22 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source