Results 81 to 90 of about 699,523 (337)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Asymptotic behavior of solutions of a partial functional differential equation

Electronic Journal of Differential Equations, 2000
The asymptotic behavior of solutions of an asymptotically autonomous partial functional differential equation is investigated. The aim of the present paper is to extend our earlier result for ordinary functional differential equations and difference ...
Gyula Farkas
doaj  

Oscillation of certain functional differential equations [PDF]

Computers & Mathematics with Applications, 1994
The author presents several sufficient conditions for all bounded solutions to the linear system of delay differential equations \[ (-1)^{m+1}\frac {d^m y_i(t)}{d t^m}+\sum _{j=1}^{n}q_{ij}y_i(t-h_{ij})=0, \quad m\geq 1,\;i=1,2,\dots,n, \] to be oscillatory.
openaire   +1 more source

Almost periodic solutions of periodic linear partial functional differential equations

, 2018
We study conditions for the abstract periodic linear functional differential equation $\dot{x}=Ax+F(t)x_t+f(t)$ to have almost periodic with the same structure of frequencies as $f$.
Luong, Vu Trong, Van Minh, Nguyen
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Maximum Principle for Optimal Control of Neutral Stochastic Functional Differential Systems [PDF]

, 2013
In this paper, the optimal control problem of neutral stochastic functional differential equation (NSFDE) is discussed. A class of so-called neutral backward stochastic functional equations of Volterra type (VNBSFEs) are introduced as the adjoint ...
Wei, Wenning
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Reducible functional differential equations

International Journal of Mathematics and Mathematical Sciences, 1985
This is the first part of a survey on analytic solutions of functional differential equations (FDE). Some classes of FDE that can be reduced to ordinary differential equations are considered since they often provide an insight into the structure of ...
S. M. Shah, Joseph Wiener
doaj   +1 more source

On solutions of a certain nonlinear differential-difference functional equation [PDF]

Mathematica Bohemica
We investigate all the possible finite order entire solutions of the Fermat-type differential-difference functional equation $(Af(z))^2+R^2(z)(Bf^{(m)}(z+c)+Cf^{(n)}(z))^2=Q(z)$, where $m,n\in\mathbb{N}$, $A,B,C\in\mathbb{C}\setminus\{0\}$ and $R(z)$, $Q(
Rajib Mandal, Raju Biswas
doaj   +1 more source

Stability theory for functional-differential equations [PDF]

Transactions of the American Mathematical Society, 1979
We consider a system of functional differential equations x ′ ( t ) = F ( t , x ( ⋅ ) ) x’\,(t)\, = \,\mathcal {F}\,(t,\,x( \cdot )) , together with a Liapunov functional
openaire   +2 more sources