Results 81 to 90 of about 696,925 (286)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The existence and Hyers–Ulam stability of solution for an impulsive Riemann–Liouville fractional neutral functional stochastic differential equation with infinite delay of order 1<β<2 $1<\beta<2$

open access: yesBoundary Value Problems, 2019
This paper deals with the existence of solution for an impulsive Riemann–Liouville fractional neutral functional stochastic differential equation with infinite delay of order ...
Yuchen Guo   +3 more
doaj   +1 more source

Hopf Bifurcation and Chaos in a Single Inertial Neuron Model with Time Delay

open access: yes, 2004
A delayed differential equation modelling a single neuron with inertial term is considered in this paper. Hopf bifurcation is studied by using the normal form theory of retarded functional differential equations.
Babcock   +28 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

A Survey of Some Current Research in Functional-differential Equations [PDF]

open access: yes
Functional differential equation applications using geometric ...
Hale, J. K.
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Analytic solutions of a first order functional differential equation with a state derivative dependent delay

open access: yesElectronic Journal of Differential Equations, 2009
This article concerns the first-order functional differential equation $$ x'(z)=x(p(z)+bx'(z)) $$ with the distinctive feature that the argument of the unknown function depends on the state derivative.
Pingping Zhang
doaj  

Reducible functional differential equations

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1985
This is the first part of a survey on analytic solutions of functional differential equations (FDE). Some classes of FDE that can be reduced to ordinary differential equations are considered since they often provide an insight into the structure of ...
S. M. Shah, Joseph Wiener
doaj   +1 more source

On solutions of a certain nonlinear differential-difference functional equation [PDF]

open access: yesMathematica Bohemica
We investigate all the possible finite order entire solutions of the Fermat-type differential-difference functional equation $(Af(z))^2+R^2(z)(Bf^{(m)}(z+c)+Cf^{(n)}(z))^2=Q(z)$, where $m,n\in\mathbb{N}$, $A,B,C\in\mathbb{C}\setminus\{0\}$ and $R(z)$, $Q(
Rajib Mandal, Raju Biswas
doaj   +1 more source

Gradient Bounds for Solutions of Stochastic Differential Equations Driven by Fractional Brownian Motions [PDF]

open access: yes, 2011
We study some functional inequalities satisfied by the distribution of the solution of a stochastic differential equation driven by fractional Brownian motions.
Cheng Ouyang   +3 more
core  

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