Results 111 to 120 of about 72,923 (307)

Almost surely asymptotic stability of neutral stochastic differential delay equations with Markovian switching [PDF]

, 2008
The main aim of this paper is to discuss the almost surely asymptotic stability of the neutral stochastic differential delay equations (NSDDEs) with Markovian switching.
Yuan, Chenggui, Chenggui Yuan, Shen, Yi, Mao, Xuerong, National Natural Science Foundation of China (Funder), , EPSRC (U.K.) (Funder), EPSRC (U.K.) (Funder), , National Natural Science Foundation of China (Funder)   +7 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Multiple solutions of nonlinear partial functional differential equations and systems

Electronic Journal of Qualitative Theory of Differential Equations, 2019
We shall consider weak solutions of initial-boundary value problems for semilinear and nonlinear parabolic differential equations with certain nonlocal terms, further, systems of elliptic functional differential equations.
László Simon
doaj   +1 more source

Evolution equations with causal operators [PDF]

, 2015
In this paper we present an existence result for causal functional evolution equations. The result is obtained under a condition with respect to the Hausdorff measure of noncompactness.
Arshad, Sadia, O'Regan, Donal, Agarwal, Ravi P., Lupulescu, Vasile   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Razumikhin-type theorem on time-changed stochastic functional differential equations with Markovian switching

Open Mathematics, 2019
This work is mainly concerned with the exponential stability of time-changed stochastic functional differential equations with Markovian switching. By expanding the time-changed Itô formula and the Razumikhin theorem, we obtain the exponential stability ...
Zhang Xiaozhi, Yuan Chenggui
doaj   +1 more source

The numerical solution of forward–backward differential equations: Decomposition and related issues [PDF]

, 2010
NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Computational and Applied Mathematics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and ...
Ford, Neville J., Lumb, Patricia M., Lima, Pedro M., Teodoro, M. Filomena   +3 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Mixed-Type Functional Differential Equations: A $C_{0}$-Semigroup Approach

Communications in Advanced Mathematical Sciences, 2018
In this paper we study certain systems of mixed-type functional differential equations, from the point of view of the $C_{0}$-semigroup theory. In general, this type of equations are not well-posed as initial value problems.
Luis Gerardo Mármol, Carmen Judith Vanegas   +1 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source