Results 51 to 60 of about 796,111 (314)

Depression in patients with chronic low back pain

Egyptian Rheumatology and Rehabilitation, 2019
Background Low back pain is a common health issue affecting at least 80% of individuals during their lifetime. It is usually recurrent and develops into chronic low back pain (CLBP).
N Nassar, N Assaf, D Farrag, D Ibrahim, A Al-Sheekh   +4 more
doaj   +1 more source

Ageing and functional disability: An unbreakable bond

Indian Journal of Community Medicine, 2023
This study aimed to assess the predominant predictors of functional disability in terms of involvement of activity of daily living (ADL) of urban geriatric subjects of Varanasi, India.
Priya Keshari, Hari Shankar
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Depression and Life Satisfaction Among Middle-Aged and Older Adults: Mediation Effect of Functional Disability

Frontiers in Psychology, 2021
With increasing age, middle-aged and older persons face a series of physical and mental health problems. This study aimed to explore the latent relationships among age, functional disability, depression, and life satisfaction. The data were obtained from
An Li, Dewen Wang, Shengnan Lin, Meijie Chu, Shiling Huang, Chun-Yang Lee, Yi-Chen Chiang   +6 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Augmented Reality and Functional Skills Acquisition Among Individuals With Special Needs: A Meta-Analysis of Group Design Studies [PDF]

, 2022
Augmented reality (AR) has the potential to support individuals with special needs and to enable their development of daily living skills. This meta-analysis study examined the effect of AR on functional skills acquisition across individuals affected by ...
Borenstein H. L., Borenstein M., Drury-Stotz M, Escobedo L., Gün E. T., Jordan R, Ozdemir M., Tekedere H., Toglia J., Westling D. L.   +9 more
core   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Functional connectivity changes and their relationship with clinical disability and white matter integrity in patients with relapsing-remitting multiple sclerosis [PDF]

, 2015
Background and objective: To define the pathological substrate underlying disability in multiple sclerosis by evaluating the relationship of resting-state functional connectivity with microstructural brain damage, as assessed by diffusion tensor maging ...
Filippini, N, Pantano, Patrizia, Petsas, Nikolaos, Piattella, MARIA CRISTINA, Pozzilli, Carlo, Prosperini, Luca, Sbardella, Emilia, Tona, Francesca, Upadhyay, Neeraj   +8 more
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Association between polypharmacy and the risk of requiring long‐term care among community‐dwelling older residents: A retrospective cohort study

Journal of General and Family Medicine
Background Polypharmacy has been increasing attention as it is associated with a number of health problems, especially adverse outcomes in older adults.
Kengo Maeda, Shin‐Ya Kawashiri, Kazuhiko Arima, Tetsuro Niri, Yukiko Honda, Jun Miyata, Fumiaki Nonaka, Hirokazu Kumazaki, Takahiro Maeda, Yasuhiro Nagata   +9 more
doaj   +1 more source