Results 81 to 90 of about 5,240 (291)

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

The discourse function of inverse voice: An experimental study in Teribe (Chibchan)

, 2010
Quesada JD, Skopeteas S. The discourse function of inverse voice: An experimental study in Teribe (Chibchan). Journal of Pragmatics. 2010;42(9):2579-2600.It has been argued that the use of inverse voice in languages with pragmatic inversion depends on ...
J. Diego Quesada, Stavros Skopeteas, Quesada, J. Diego, Skopeteas, Stavros   +3 more
core   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Morphosyntax and its generation in Functional Discourse Grammar: what can be learned from Role and Reference Grammar?

Alfa: Revista de Lingüística, 2007
<p>The morphosyntactic level in Functional Discourse Grammar (FDG) is currently underdeveloped. The aim of the present paper is to make proposals relevant to the structure of the morphosyntactic level in this theory, and to how the interpersonal ...
Christopher S. Butler
doaj  

Syntactic discontinuity in a dynamic model of expression rules

Journal of English Studies, 2004
This journal article addresses the question of the implementation of a dynamic model of expression rules in Functional Grammar (Dik 1997a, b) by considering sintactic discontinuity in Old English, a topic which has far-reaching methodological and ...
Francisco Javier Martín Arista
doaj   +1 more source

Heterointerface Engineering of Bismuth Nanosheets/Nitrogen‐Doped Carbon Nanoleaves Enables High‑Performance Electrochemical Dechlorination

Advanced Science, EarlyView.
Bismuth nanosheets integrated with nitrogen‐doped carbon nanoleaves are constructed via a 2D‐on‐2D heterointerface engineering strategy. The resulting BiNS/NCL electrode delivers high chloride adsorption capacity, fast kinetics, and stable cyclability. A built‐in electric field at the heterointerface promotes chloride electrosorption and stabilizes the
Bohan Liu, Feifei Pang, Xingtao Xu, Duo Yang, Xi Yu, Sikan Yang, Jiarui Hao, Nithima Khaorapapong, Zhichang Xiao, Xiaoxian Zhao, Yusuke Yamauchi, Shuaihua Zhang   +11 more
wiley   +1 more source

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

A Pragmacognitive Approach to the Study of some Internet Scientific Articles: Headline Titles

Miscelánea: A Journal of English and American Studies, 2003
The proliferation of new media and electronics modes of communication in public life, and the recent increase in the interdisciplinary nature of academic and professional discourse, has brought about an increasing appropriation of lexicogrammatical ...
Mª Isabel González Pueyo, Alicia Redrado Lacarta   +1 more
doaj   +1 more source

Terms, clauses and constructions in Functional Grammar [PDF]

, 2003
This article offers a critical evaluation of Functional Grammar (Dik, 1997a,b) by focusing on the main theoretical constructs of the theory, namely clauses, term phrases and complex constructions (clauses, noun phrases and complex sentences, respectively,
Arista, J.M. [0000-0001-9900-0104]
core   +1 more source