Results 131 to 140 of about 5,382,530 (248)

Gastrointestinal functional disorders can benefit from the use of medical devices made of substances. [PDF]

Front Drug Saf Regul, 2023
Savarino V, Marabotto E, Zentilin P, Furnari M, Bodini G, Giovanni Giannini E, Vincenzo Savarino E.   +6 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Pharmacological and pharmacokinetic aspects of functional gastrointestinal disorders

, 2006
Medications are commonly used for the treatment of patients with functional gastrointestinal disorders. The general goal of this report is to review the pharmacokinetics and pharmacology of medications used in functional gastrointestinal disorders ...
Camilleri M., DE PONTI, FABRIZIO, Fioramonti J., Lydiard R. B., Tack J., Bueno L.   +5 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Symptom Perceptions in Functional Disorders, Major Health Conditions, and Healthy Controls: A General Population Study. [PDF]

Clin Psychol Eur, 2022
Weigel A, Meinertz Dantoft T, Jørgensen T, Carstensen T, Löwe B, Weinman J, Frostholm L.   +6 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

[Pathogenesis of functional gastrointestinal disorders - an interdisciplinary perspective]

, 2010
Functional gastrointestinal disorders (FGD) are highly prevalent worldwide. Recent research demonstrates that complex and interacting biological and behavioral mechanisms contribute particularly to the pathogenesis of irritable bowel syndrome and ...
Egloff, N, Beer, C, Gschossmann, J M, Sendensky, A H, von Känel, R   +4 more
core  

Functional disorders and chronic pain. [PDF]

Clin Med (Lond), 2021
Sawyer R.
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

IoT in medical diagnosis: detecting excretory functional disorders for Older adults via bathroom activity change using unobtrusive IoT technology. [PDF]

Front Public Health, 2023
Abdulrazak B, Mostafa Ahmed H, Aloulou H, Mokhtari M, Blanchet FG.   +4 more
europepmc   +1 more source