Results 231 to 240 of about 7,721,508 (349)

Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi. [PDF]

Angew Chem Int Ed Engl
Sokolova N, Denisov SS, Hackl T, Haslinger K.   +3 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

CD47/SIRPα pathways: Functional diversity and molecular mechanisms. [PDF]

World J Biol Chem
Bhardwaj N, Chandra H, Singh A, Babu R.
europepmc   +1 more source

Assessing functional diversity: the influence of the number of the functional traits

Theoretical Ecology, 2019
G. Legras, Nicolas Loiseau, J. Gaertner, Jean-Christophe, Poggiale, N. Gaertner-Mazouni   +5 more
semanticscholar   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Isoform differences drive functional diversity of NHR-49. [PDF]

MicroPubl Biol
Tatge L, Douglas PM.
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Exploring <i>Bacteroidota</i> strains from human stool and animal feces: phenotyping and functional diversity. [PDF]

Microlife
Ladewig L, Kinfu BM, Fokt H, Bethge H, Tufail MA, Baines JF, Schmitz RA.   +6 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source