Results 61 to 70 of about 1,214,259 (255)

Natural selection reduced diversity on human Y chromosomes [PDF]

, 2013
The human Y chromosome exhibits surprisingly low levels of genetic diversity. This could result from neutral processes if the effective population size of males is reduced relative to females due to a higher variance in the number of offspring from males
Lohmueller, Kirk E., Nielsen, Rasmus, Sayres, Melissa A. Wilson   +2 more
core   +5 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Complex Behavior in Simple Models of Biological Coevolution

, 2006
We explore the complex dynamical behavior of simple predator-prey models of biological coevolution that account for interspecific and intraspecific competition for resources, as well as adaptive foraging behavior.
Krebs C. J., Krebs C. J., Kuang Y., PER ARNE RIKVOLD, Resit H., Verhulst P. F.   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Pattern of functional diversity along the elevation gradient in the dry evergreen Afromontane forest of Hararghe Highland, Southeast Ethiopia

Biosystems Diversity, 2020
Understanding plant species distribution patterns along environmental gradients is fundamental to managing ecosystems, particularly when habitats are fragmented due to intensive human land use pressure.
M. Teshome, Z. Asfaw, M. Mohammed
doaj   +1 more source

Functional diversity of motoneurons in the oculomotor system [PDF]

, 2019
Extraocular muscles contain two types of muscle fibers according to their innervation pattern: singly innervated muscle fibers (SIFs), similar to most skeletal muscle fibers, and multiply innervated muscle fibers (MIFs).
Blumer, Roland, García Hernández, Rosendo Miguel, Martín Calvo, Paula, Pastor Loro, Ángel Manuel, Rodríguez de la Cruz, Rosa María   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Functional diversity of natural IgM [PDF]

International Immunology, 1999
This paper proposes a method for the quantitative characterization of repertoire diversity of an unknown mixture of antibodies on the basis of its reactivity profile in the quantitative immunoblot (QIB). The QIB is calibrated by measuring the reactivity profiles of supernatants of known 'diversity' (i.e. known numbers of B cell clones).
C, Brissac, A, Nobrega, J, Carneiro, J, Stewart   +3 more
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Atlantic Dung Beetle Traits: A comprehensive dataset of functional traits for dung beetles (Coleoptera, Scarabeidae, Scarabaeinae) in the Atlantic Forest [PDF]

Biodiversity Data Journal
Functional traits offer critical insights into species performance, survival strategies and ecological interactions. However, the availability of comprehensive trait datasets remains limited, primarily due to the substantial effort required for field ...
Paula Ribeiro Anunciação, André Batista Tavares, Maria Maldaner, Fernando Vaz-de-Mello, Milton Ribeiro, Raffael Ernst   +5 more
doaj   +3 more sources