Results 211 to 220 of about 9,328,051 (330)

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Functional Nutrition Literacy and Healthy and Sustainable Eating Efforts Across Diverse Populations. [PDF]

J Hum Nutr Diet
Jáuregui A, Ramírez-Contreras EJ, Quevedo Torres KL, Contreras-Manzano A, White CM, Arellano-Gómez LP, Barquera S, Hammond D, Davis RE, Thrasher JF.   +9 more
europepmc   +1 more source

Long‐Lifespan Polyorganosiloxane‐Based Silicone Evaporator for High‐Efficiency Seawater Desalination

Advanced Science, EarlyView.
Conventional evaporators suffer from salt crystallization and degradation. We design a white polyorganosiloxane evaporator with a reflector, achieving 4.344 kg m−2 h−1 at 1 sun in 3.5 wt.% NaCl. It shows over 53‑day cycling stability and 197‑day seawater resistance.
Jiaxian Zheng, Liqiang Zhang, Haoqi Ni, Shuozhen Chen, Xiangfeng Lin, Liwei Wang, Zhanhui Yuan   +6 more
wiley   +1 more source

Cross-National Analysis of Consumer Preferences to Oat-Banana-Drinks With <i>Alaria esculenta</i> in Germany and Scotland. [PDF]

Food Sci Nutr
Engelhardt L, Wilkin JD.
europepmc   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source

Additives with Emerging Health Concerns in Ultra-Processed Sweetened Beverages Sold in the United States: Preservatives, Artificial Sweeteners, and Added Sugars. [PDF]

Nutrients
Dunford EK, Calvo MS, Uribarri J.
europepmc   +1 more source

Histone Lactylation Drives WNK1 Expression to Promote Esophageal Squamous Cell Carcinoma Progression Through Histone H3 Ser10 Phosphorylation

Advanced Science, EarlyView.
In brief. Yan et al. demonstrated that the excess lactate produced by the enhanced glycolysis pathway in esophageal cancer can lactylate H3K23, H3K23la can be enriched in the WNK1 promoter region to promote WNK1 expression, thereby increasing the phosphorylation of the p‐H3 Ser10 site, and p‐H3S10 can be enriched in the AKT1 promoter region to promote ...
Mingyang Yan, Shaobo Fang, Yanming Song, Lei Zhang, Kexin Zhao, Zhenwei Wang, Yang Shao, Meng Liu, Xinyang Jia, Qinxin Guo, Mee‐Hyun Lee, Guoguo Jin, Zigang Dong   +12 more
wiley   +1 more source

Lactate Drives Pathological Browning of White Adipose Tissue to Aggravate Sepsis‐Associated Metabolic Disorders in a GPR81‐Dependent Manner

Advanced Science, EarlyView.
Sepsis‐triggered lactate accumulation induces pathological white adipose tissue browning. Lactate activates adipocyte GPR81 to sequentially upregulate CTRP6‐p38 signalling and UCP1 expression. This cascade exacerbates sepsis‐associated metabolic disorders.
Chunliang Zheng, Xiaohua Li, Shuo Li, Chungen Xing, Chun Cao   +4 more
wiley   +1 more source

Brain and physiological responses to flavored waters with different sweeteners: a randomized crossover study in healthy young adults. [PDF]

Am J Clin Nutr
Smeets PA, Veit R, Oosterink E, Meijboom S, Risso D, Preissl H, Kullmann S.   +6 more
europepmc   +1 more source

Loss of Lepr in Fibroblasts Drives Tumor Development by Promoting Macrophage Infiltration

Advanced Science, EarlyView.
TNFα and TGFβ signaling reprograms Lepr+ fibroblasts toward a LeprnegMmphigh inflammatory CAF (iCAF) state, with downregulation of the Tcf21‐Lepr axis contributing to this transition. Lepr loss induces Csf3, which contributes to the enhanced macrophage‐recruiting capacity of these iCAFs, thereby promoting tumor development. Thus, inflammatory signaling
Manyu Song, Wuqi Yang, Bangran Qi, Liyuan Hou, Xu Yang, Jiuzhi Xu, Shengyuan Tian, Shuiling Jin, Lu Yu, Zhengquan Yu, Min Deng, Jiaqiang Huang, Suoqin Jin, Cong Lv   +13 more
wiley   +1 more source