Results 111 to 120 of about 565,177 (286)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The influence of aerodynamic coefficients on the elements of classic projectile paths

Vojnotehnički Glasnik, 2011
The article deals with the results of the research on the influence of aerodynamic coefficient values on the trajectory elements and the stability parameters of classic axisymmetric projectiles.
Damir D. Jerković, Dušan B. Regodić
doaj   +1 more source

ON THE DIRICHLET PROBLEMS FOR SYMMETRIC FUNCTION EQUATIONS OF THE EIGENVALUES OF THE COMPLEX HESSIAN [PDF]

Asian Journal of Mathematics, 2004
Let \( D\) be a smoothly bounded domain in \( {\mathbb C}^n \). The author investigates the existence and uniqueness of solutions \( u\) for Dirichlet problems \( f(\lambda(H(u)))=\psi \) in \( \overline{D} \), \( u=\phi \) on \( \partial D \), where \( \lambda(H(u)) \) denotes the eigenvalues of the complex Hessian of \( u \) and \( f \) is a ...
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

The description of entire solutions for some class of complex nonlinear partial differential equation (systems) in C2 ${\mathbb{C}}^{2}$

Demonstratio Mathematica
This article focuses on describing the entire solutions of complex nonlinear partial differential equation (systems) with two variables. Utilizing Nevanlinna theory along with the Hadamard factorization theory of meromorphic functions, we derive several ...
Chen Yu Bin, Jiao Xin, Xu Hong Yan
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Extended non-Markovian stochastic Schrödinger equation with complex frequency modes for general basis functions

The Journal of Chemical Physics
We introduce an extended formulation of the non-Markovian stochastic Schrödinger equation with complex frequency modes (extended cNMSSE), designed for simulating open quantum system dynamics under arbitrary spectral densities. This extension employs non-exponential basis sets to expand the bath correlation functions, overcoming the reliance of the ...
Yukai Guo, Zeyu Huang, Xing Gao
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source