Results 131 to 140 of about 3,570,719 (299)

Physical Activity and Functional Fitness of Students

Sport i Turystyka
Research demonstrates that 45% of Europeans do not participate in physical activity, and unhealthy lifestyle habits acquired during college years can persist into adulthood. Undertaking physical activity brings many benefits but also a greater likelihood
Bartłomiej Patryk Hes, Halina Guła-Kubiszewska, Wojciech Starościak, Ewa Skorupka   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Adding weights to low intensity exercise increases isometric muscular strength and functional ability in healthy older adults

, 2009
One of the most pronounced changes associated with aging is the impairment of movement, related in part to decreased strength. This study evaluated the effect of using hand-held and ankle weights on isometric strength and functional ability with a group
de Paleville, Daniela Terson, Bradley, Sherri, Topp, Robert, Swank, Ann Marie, Funk, Daniel   +4 more
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Sports Medicine & Fitness News (1986 Summer)

, 1986
Sports Medicine Fitness Center. (1986). Sports Medicine & Fitness News (1986 Summer).
Sports Medicine Fitness Center
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Changes in Fitness, physical activity, fatness, and screen time: A longitudinal study in children and adolescents [PDF]

, 2009
*_Objective:_* To analyze whether changes in Physical Activity Index (PAI), sedentary time (ST; TV and PC use), and Body Mass Index (BMI) made a significant contribution to longitudinal changes in Physical Fitness (PF) of children and adolescents ...
Clarice Martins, Lars Bo Andersen, Denisa Mendonça, Maria Paula Santos, Jose Ribeiro, Gustavo Silva, Jorge Mota, Luisa Aires   +7 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Sports Medicine & Fitness News (1985 Winter)

, 1985
Sports Medicine Fitness Center. (1985). Sports Medicine & Fitness News (1985 Winter).
Sports Medicine Fitness Center
core  

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source