Results 111 to 120 of about 3,570,719 (299)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Association Between Perceived Social Support and Depressive Symptoms Among Stroke Survivors Undergoing Rehabilitation in Kinshasa, Democratic Republic of Congo: A Cross-Sectional Study

Annals of Medicine and Medical Sciences
Background: Post-stroke depression (PSD) is a frequent neuropsychiatric complication associated with poor functional recovery and reduced quality of life.
Eric Kam, Guy Bumoko, Chloé Sauvage, Willy Katosia, Teddy Bofosa, Naomie Ngisia, Daniel Okitundu, Betty Miangindula   +7 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Reimagining Aging: A Systematic Review and Meta-analysis of Virtual Reality on Cognitive, Physical, and Functional Outcomes in Older Adults

Journal of Mid-Life Health
The diverse applications of virtual reality (VR) for older adults require a need for comprehensive, updated syntheses, and research to understand VR’s effectiveness across cognitive, physical, and functional domains.
Charu Chhabra, Sohrab Ahmad Khan, Varsha Chorsiya, Habiba Sundus, Harsirjan Kaur, Mohd. Mazhar, Harpreet Singh, Archita Agarwal   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Profile of Muscular Strength, Endurance, and Movement Patterns in Recreational Individuals Performing Targeted Strength Training

Central European Journal of Sport Sciences and Medicine
This study aimed to assess muscular strength, endurance, and movement pattern quality in adults engaged in recreational, targeted strength training compared to physically active individuals without a specific strength focus.
Szymon Lubkowski, Beata Pluta
doaj   +1 more source

A Comparison of Children’s Fitness in the Northwest and Southwest of England [PDF]

, 2014
The data from this paper was gathered from a larger cross-sectional study examining children’s physical activity participation in the Northwest and the Southwest of England. The purpose of this study was to carry out a battery of health and fitness tests
Boyle, Spencer
core   +1 more source

Sports injury prevalence and associated factors in functional fitness: a cross-sectional study

Purpose We investigated injury rates over the previous 12 months, associated factors, and injury characteristics in a cohort of recreational functional fitness training participants.
Karina Ayumi Martins Utida, Denise Cruz Carvalho Gomes, Paula Felippe Martinez, Fábio de Souza Ajala, Silvio Assis de Oliveira-Junior   +4 more
core   +1 more source

Age-related decrease in physical activity and functional fitness among elderly men and women

, 2013
Zoran Milanovic,1 Saša Pantelic,1 Nebojša Trajkovic,1 Goran Sporiš,2 Radmila Kostic,1 Nic James31Faculty of Sport and Physical Education, University of Niš, Niš, Serbia; 2Faculty of Kinesiology, University of Zagreb ...
James N, Trajković N, Kostić R, Pantelić S, Milanović Z, Sporiš G   +5 more
core