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Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis. [PDF]
Cell Mol ImmunolXiao Z +10 more
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Statistics in Medicine, 2009
AbstractGroup sequential monitoring is used to provide guidance on stopping a clinical trial in progress based on interim evaluation of its efficacy objectives. A trial could stop because an experimental regimen (1) is efficacious, (2) lacks any sign of efficacy, or (3) is specifically less efficacious than a control.
Keaven M, Anderson, Jason B, Clark
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AbstractGroup sequential monitoring is used to provide guidance on stopping a clinical trial in progress based on interim evaluation of its efficacy objectives. A trial could stop because an experimental regimen (1) is efficacious, (2) lacks any sign of efficacy, or (3) is specifically less efficacious than a control.
Keaven M, Anderson, Jason B, Clark
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Properties of Symmetric Fitness Functions
IEEE Transactions on Evolutionary Computation, 2006The properties of symmetric fitness functions are investigated. We show that the search spaces obtained from symmetric functions have the zero-correlation structures between fitness and distance. It is also proven that symmetric functions induce a class of the hardest problems in terms of the epistasis variance and its variants.
Sung-Soon Choi +2 more
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Evolving Fitness Landscapes with Complementary Fitness Functions
2020Given an optimization problem, local search algorithms may fail to reach optimal solutions when faced to difficult and unsuitable fitness landscapes. Climbing based optimization is sensitive to unexpected distribution of local optima. In this paper, we aim at modifying the initial fitness landscape of a problem in order to better fit climbing ...
Hénaux, Vincent +2 more
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The inverse of fitting's functional
2005The evaluation of a goal for a logic program can be viewed as the search for an answer, written in the constraints language, that correctly implies the goal. We propose a small set of inference rules, correct w.r.t. the completion of a program and the Clark equational theory, which is strong enough to compute a complete set of answers for extended ...
Alberto Bottoni, Giorgio Levi
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Fitting the correlation function
Applied Optics, 2000The whole correlation function of the intensity of scattered light is usually determined from a single realization of the photocurrent. As a result, the values of the correlation function at different delay times are not statistically independent. A standard least-squares fitting procedure is not optimal for an analysis of such data.
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Fitting of multivariate functions
Proceedings of the IEEE, 1987This research presents a nonparametric algorithm for fitting of a multivariate function from noisy data. Conditions are provided that assure local and global convergence in probability. Suggestions are stated for practical use of the algorithm.
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Proceedings of the 8th ACM conference on Creativity and cognition, 2011
The process of creating art is an optimization problem for which the objective function is probably unknown and possibly undefinable. That objective function is imposed on the artist by an environment which may be composed of any of a number of sources: peers, a jury, society, the self.
David Norton, Derrall Heath, Dan Ventura
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The process of creating art is an optimization problem for which the objective function is probably unknown and possibly undefinable. That objective function is imposed on the artist by an environment which may be composed of any of a number of sources: peers, a jury, society, the self.
David Norton, Derrall Heath, Dan Ventura
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The British Journal for the Philosophy of Science, 1996
According to historical theories of biological function, a trait's function is determined by natural selection in the past. I argue that, in addition to historical functions, ahistorical functions ought to be recognized. I propose a theory of biological function which accommodates both.
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According to historical theories of biological function, a trait's function is determined by natural selection in the past. I argue that, in addition to historical functions, ahistorical functions ought to be recognized. I propose a theory of biological function which accommodates both.
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Science, 2009
Biochemistry![Figure][1] CREDIT: DUNHAM ET AL., EMBO J. 28 , 10.1038/EMBOJ.2009.120 (2009) In bacteria, low–copy number plasmids provide a model system for studying the segregation of DNA into daughter cells—partitioning requires only a centromere-like DNA site, a partition NTPase, and a centromere-binding protein.
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Biochemistry![Figure][1] CREDIT: DUNHAM ET AL., EMBO J. 28 , 10.1038/EMBOJ.2009.120 (2009) In bacteria, low–copy number plasmids provide a model system for studying the segregation of DNA into daughter cells—partitioning requires only a centromere-like DNA site, a partition NTPase, and a centromere-binding protein.
openaire +1 more source