FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Ridge Regression for Functional Form Identification of Continuous Predictors of Clinical Outcomes in Glomerular Disease. [PDF]
Glomerular Dis, 2023 Rubin J, Mariani L, Smith A, Zee J.
europepmc +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Why is the snowflake schema a good data warehouse design? [PDF]
, 2003 Database design for data warehouses is based on the notion of the snowflake schema and its important special case, the star schema. The snowflake schema represents a dimensional model which is composed of a central fact table and a set of constituent ...
Mark Levene +3 more
core +1 more source
Selecting correct functional form in consumption function: Analysis of energy demand at household level. [PDF]
PLoS One, 2022 Hina H, Abbas F, Qayyum U.
europepmc +1 more source
A Cartographic Analysis of the Syntactic Structure of Mandarin Ba
Studies in Chinese Linguistics, 2018 This paper analyzes the syntactic properties of the “ba-construction” or “disposal form” in Mandarin Chinese under new theoretical frameworks. By introducing the event-decomposition method proposed by Ramchand (2008), it argues that the ba-construction ...
Sun Yangyu
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Application of SHAP values for inferring the optimal functional form of covariates in pharmacokinetic modeling. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2022 Janssen A +4 more
europepmc +1 more source
Assessing Persian translation of selected rhetorical figures in Venus and Adonis and The Rape of Lucrece by Shakespeare [PDF]
مطالعات زبانی و بلاغیRhetorical figures are the artistic use of language that, through the selection of specific linguistic and grammatical structures, assist poets in expressing their ideas and thoughts.
Abolfazl Horri
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source