Results 71 to 80 of about 11,010,737 (246)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A novel method to define personalized post-orthodontic treatment dental arch form

BMC Oral Health
Background The dental arch is a fundamental aspect of orthodontic treatment and has considerable implications in planning and therapy. Since arch forms differ (e.g.
Yingying Su, Jiachao Zhang, Hanyan Ma, Xu Zheng   +3 more
doaj   +1 more source

De la forme urbaine à la structure métropolitaine : une typologie de la configuration interne des densités pour les principales métropoles européennes de l’Audit Urbain

Cybergeo, 2015
We analyze eight dimensions of the spatial structure of metropolitan regions in Europe. Our research is based on recent literature on the quantification of internal configurations of densities.
Florent Le Néchet
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Usefulness of the WAIS‐IV Short Form for Measuring Cognitive Function in Patients With Schizophrenia

Neuropsychopharmacology Reports
Schizophrenia causes cognitive dysfunction. The assessment of cognitive function is important in the treatment of schizophrenia. The Wechsler Adult Intelligence Scale (WAIS) is used to assess cognitive function in patients with psychiatric disorders. For
Satsuki Ito, Chika Sumiyoshi, Junya Matsumoto, Kenichiro Miura, Yuka Yasuda, Naomi Hasegawa, Harumasa Takano, Tomiki Sumiyoshi, Ryota Hashimoto   +8 more
doaj   +1 more source

Understanding the functional form of the relationship between childhood cognitive ability and adult financial well-being. [PDF]

PLoS One, 2023
Gladstone J, Barrett JAM.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Assessing Persian translation of selected rhetorical figures in Venus and Adonis and The Rape of Lucrece by Shakespeare [PDF]

مطالعات زبانی و بلاغی
Rhetorical figures are the artistic use of language that, through the selection of specific linguistic and grammatical structures, assist poets in expressing their ideas and thoughts.
Abolfazl Horri
doaj   +1 more source

Ridge Regression for Functional Form Identification of Continuous Predictors of Clinical Outcomes in Glomerular Disease. [PDF]

Glomerular Dis, 2023
Rubin J, Mariani L, Smith A, Zee J.
europepmc   +1 more source