Results 51 to 60 of about 2,464,663 (310)

Optimal designs for testing the functional form of a regression via nonparametric estimation techniques [PDF]

open access: yes, 2000
For the problem of checking linearity in a heteroscedastic nonparametric regression model under a fixed design assumption we study maximin designs which maximize the minimum power of a nonparametric test over a broad class of alternatives from the ...
Stefanie Biedermann   +3 more
core   +1 more source

Funktionskreis and the stratificational model of semiotic structures: Jakob von Uexküll, Luis Prieto and Louis Hjelmslev

open access: yesSign Systems Studies, 2019
The main aim of this article is to show how a possible theoretical articulation between Uexküll’s notion of Funktionskreis and the stratificational model of semiotic structures proposed by Louis Hjelmslev can be made.
E. Israel Chávez Barreto
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Functional forms and educational production functions [PDF]

open access: yesEconomics Letters, 1985
Abstract Different functional forms are proposed and applied in the context of educational production functions. Policy implications of such an approach in terms of school interventions are discussed in the paper.
Montmarquette, C., Mahseredjian, S.
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The evolutionary origin of form and function [PDF]

open access: yesThe Journal of Physiology, 2014
AbstractWe regard the basic unit of the organism, the cell, as a complex dissipative natural process functioning under the second law of thermodynamics and the principle of least action. Organisms are conglomerates of information bearing cells that optimise the efficiency of energy (nutrient) extraction from its ecosystem.
Keith, Baverstock, Mauno, Rönkkö
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Calculating Total Factor Productivity and Substitution Elasticities in the Manufacturing Sector in Iran [PDF]

open access: yesفصلنامه پژوهش‌های اقتصادی ایران, 2018
The main aim of this paper is to estimate updated and accurate measurement of total factor productivity (TFP), price and substitution elasticities in the manufacturing sector in Iran over the period 1974-2013 by using a locally flexible normalized ...
Elaheh Asadi Mehmandosti   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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