Results 101 to 110 of about 2,588,001 (311)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Clustering Plasmodium falciparum Genes to their Functional Roles Using k-means [PDF]

, 2010
We developed recently a new and novel Metric Matrics k-means (MMk-means) clustering algorithm to cluster genes to their functional roles with a view of obtaining further knowledge on many P. falciparum genes.
Adebiyi, E. F., Doumbia, Seydou, Osamor, V. C.   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A framework for list representation, enabling list stabilization through incorporation of gene exchangeabilities

, 2011
Analysis of multivariate data sets from e.g. microarray studies frequently results in lists of genes which are associated with some response of interest.
Fontes, Magnus, Soneson, Charlotte
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Single-molecule direct RNA sequencing reveals the shaping of epitranscriptome across multiple species

Nature Communications
N6-methyladenosine (m6A) is an essential RNA modification that regulates gene expression and influences diverse cellular processes. Yet, fully characterizing its transcriptome-wide landscape and biogenesis mechanisms remains challenging. Traditional next-
Ying-Yuan Xie, Zhen-Dong Zhong, Hong-Xuan Chen, Ze-Hui Ren, Yuan-Tao Qiu, Ye-Lin Lan, Fu Wu, Jin-Wen Kong, Ru-Jia Luo, Delong Zhang, Biao-Di Liu, Yang Shu, Feng Yin, Jian Wu, Zigang Li, Zhang Zhang, Guan-Zheng Luo   +16 more
doaj   +1 more source

Overexpression of the Arabidopsis SRRM1L gene increases soybean saline–alkali tolerance without yield penalty

Crop Journal
Saline–alkali stress is becoming a major global issue due to environmental degradation, hindering plant growth and reducing both seed yield and quality of many crops, including soybean.
Xin Liu, Qi Sun, Haishan Liu, Yuanyuan Zhao, Xin Zhao, Pengtao Pan, Minglong Li, Qiang Li, Jialei Xiao, Zhangxiong Liu, Xiaohuan Sun, Pengfei Xu, Shuzhen Zhang, Xiaodong Ding   +13 more
doaj   +1 more source

A Novel Bioinformatic Approach to Understanding Addiction [PDF]

, 2017
Finding the genetic markers that influence complex, multigenic substance addiction phenotypes has been an area of significant medical study. Understanding complex disease traits like addiction has been hampered by the lack of functional insights into ...
Jackson, Latifa F.
core   +1 more source

Random-set methods identify distinct aspects of the enrichment signal in gene-set analysis

, 2007
A prespecified set of genes may be enriched, to varying degrees, for genes that have altered expression levels relative to two or more states of a cell.
Ahlquist, Paul, Boon, Johan A. den, Newton, Michael A., Quintana, Fernando A., Sengupta, Srikumar   +4 more
core   +1 more source