Results 181 to 190 of about 56,894 (219)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source
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Mycorrhizas: Gene to function

Plant and Soil, 2005
Substantial progress has been made toward development of molecular tools for identification and quantification of mycorrhizal fungi in roots and evaluation of the diversity of ectomycorrhizal (ECM) fungi and the phylogeny and genetic structure of arbuscular mycorrhizal (AM) fungi.
James H. Graham, R. Michael Miller
openaire   +1 more source

Gene function

Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie, 2000
The problem of gene function--of the relationships between hereditary material and the characteristics of organisms--preceded the rediscovery of Mendel's laws and accompanied the development of genetics in the XXth century. Molecular biologists replaced the simple gene-character relationship by two relationships: the first, between genes and proteins ...
openaire   +2 more sources

Genes and erectile function

Current Opinion in Urology, 2003
Few human studies have been performed with specific genetic endpoints coupled with erectile function or dysfunction. Most knowledge of gene expression and the function thereof on penile erection has been acquired in experimental models. The purpose of the present review is to give an overview of the available information obtained in studies of genes or
openaire   +2 more sources

Attributing functions to genes and gene products

Trends in Biochemical Sciences, 2011
A major focus of modern biochemical, biophysical and cell biological research is the attribution of function to elements of structure: gene products, genes and higher-order cellular structures. Misunderstandings and controversies can arise in connection with such assignments, in part because of the logical complexity inherent in the relating of ...
openaire   +2 more sources

Termites as Functional Gene Resources

Recent Patents on Biotechnology, 2009
Termites (Dictyoptera, Isoptera) comprise a complex assemblage of diverse species, roughly divided into so-called lower and higher termites. Lower termites harbor a dense and diverse population of prokaryotes and flagellated protists (single-cell eukaryotes) in their gut.
Toru, Matsui   +2 more
openaire   +2 more sources

Imprinted genes and neuroendocrine function

Frontiers in Neuroendocrinology, 2008
Imprinted genes are monoallelically expressed in a parent-of-origin dependent manner. Whilst the full functional repertoire of these genes remains obscure, they are generally highly expressed in the brain and are often involved in fundamental neural processes.
William, Davies   +3 more
openaire   +2 more sources

Multiple functions of Dlx genes

The International Journal of Developmental Biology, 2000
Dlx genes comprise a highly conserved family of homeobox genes homologous to the distal-less (Dll) gene of Drosophila. They are thought to act as transcription factors. All Dlx genes are expressed in spatially and temporally restricted patterns in craniofacial primordia, basal telencephalon and diencephalon, and in distal regions of extending ...
G R, Merlo   +5 more
openaire   +2 more sources

Gene function, gene networks and the fate of duplicated genes

Seminars in Cell & Developmental Biology, 1999
For both copies of a duplicated gene to become fixed in a population and subsequently maintained, selection must favour individuals with both genes over individuals with one. Here I review and assess some of the proposed ways that gene structure and function might affect the likelihood of both copies acquiring distinct functions and therefore positive ...
openaire   +2 more sources

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