Results 311 to 320 of about 2,594,564 (358)

DNA Methylation and Gene Function

Science, 1980
In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of many cytosine residues to 5-methylcytosine. For several years, control of gene activity by DNA methylation has been recognized as a logically attractive possibility, but experimental support has proved elusive.
A, Razin, A D, Riggs
openaire   +2 more sources

Functional Gene Variants of CYP3A4

Clinical Pharmacology & Therapeutics, 2014
Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more drugs in clinical use than any other foreign compound-metabolizing enzyme in humans. Recently, increasing evidence has been found showing that variants in the CYP3A4 gene have functional significance and--in rare cases--lead to loss of activity, implying tremendous consequences for ...
A N, Werk, I, Cascorbi
openaire   +2 more sources

Gene Function Analysis

2017
In Chap. 5, a granular self-organizing network for clustering and a methodology for gene ranking using the concept of granularity are described.
Sankar K. Pal, Shubhra S. Ray, Avatharam Ganivada   +2 more
openaire   +1 more source

Analysing gene function after duplication

BioEssays, 2001
AbstractAfter gene duplication, mutations cause the gene copies to diverge. The classical model predicts that these mutations will generally lead to the loss of function of one gene copy; rarely, new functions will be created and both duplicate genes are conserved.
T, Massingham, L J, Davies, P, Liò
openaire   +2 more sources

Termites as Functional Gene Resources

Recent Patents on Biotechnology, 2009
Termites (Dictyoptera, Isoptera) comprise a complex assemblage of diverse species, roughly divided into so-called lower and higher termites. Lower termites harbor a dense and diverse population of prokaryotes and flagellated protists (single-cell eukaryotes) in their gut.
Toru, Matsui, Gaku, Tokuda, Naoya, Shinzato   +2 more
openaire   +2 more sources

Imprinted genes and neuroendocrine function

Frontiers in Neuroendocrinology, 2008
Imprinted genes are monoallelically expressed in a parent-of-origin dependent manner. Whilst the full functional repertoire of these genes remains obscure, they are generally highly expressed in the brain and are often involved in fundamental neural processes.
William, Davies, Phoebe M Y, Lynn, Dinko, Relkovic, Lawrence S, Wilkinson   +3 more
openaire   +2 more sources

Wilms' tumour gene and function

Current Opinion in Genetics & Development, 1993
The Wilms' tumour gene, WT1, encodes a protein with four zinc fingers that is probably a transcription factor. In humans, WT1 mutations can lead to childhood kidney tumours and to developmental defects of the kidney and gonad. The WT1 gene may have a role in the mesenchyme to epithelial switch in a range of mesodermally derived tissues.
openaire   +2 more sources

Function: Gene Action

1971
This review is intended to document some important trends in this field rather than to give a complete survey of the articles which are flooding the literature. The examples are chosen sometimes quite arbitrarily with the only goal being to document certain concepts.
openaire   +1 more source

Regucalcin Evolution and Gene Function

2020
The ability to synthetize ascorbic acid has been lost multiple times in animals always due to mutations in the terminal gene (GULO) of the Vitamin C synthesis pathway. This suggests that the other genes of the pathway perform other essential functions besides participating in the synthesis of Vitamin C.
openaire   +2 more sources

Baculovirus genes affecting host function

In Vitro Cellular & Developmental Biology - Animal, 2009
Baculoviruses are insect-specific viruses. These large DNA viruses encode many genes in addition to those required to replicate and build new virions. These auxiliary genes provide selective advantages to the virus for invading and infecting host insects.
openaire   +2 more sources