Results 211 to 220 of about 3,788,624 (254)
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2018
Functional genomics encompasses diverse disciplines in molecular biology and bioinformatics to comprehend the blueprint, regulation, and expression of genetic elements that define the physiology of an organism. The deluge of sequencing data in the postgenomics era has demanded the involvement of computer scientists and mathematicians to create ...
Michael Mannstadt, Marc N. Wein
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Functional genomics encompasses diverse disciplines in molecular biology and bioinformatics to comprehend the blueprint, regulation, and expression of genetic elements that define the physiology of an organism. The deluge of sequencing data in the postgenomics era has demanded the involvement of computer scientists and mathematicians to create ...
Michael Mannstadt, Marc N. Wein
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Genomics and functional genomics with haloarchaea
Archives of Microbiology, 2008The first haloarchaeal genome was published in 2000 and today five genome sequences are available. Transcriptome and proteome analyses have been established for two and three haloarchaeal species, respectively, and more than 20 studies using these functional genomic approaches have been published in the last two years.
J, Soppa +5 more
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Mechanisms of Ageing and Development, 2003
Ageing is the most complex phenotype currently known, since it becomes manifest in all organs and tissues, affects an organism's entire physiology, impacts function at all levels and increases susceptibility to all major chronic diseases. Insight into the molecular and cellular targets of the ageing process would offer the unprecedented opportunity to ...
Jan, Vijg, Yousin, Suh
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Ageing is the most complex phenotype currently known, since it becomes manifest in all organs and tissues, affects an organism's entire physiology, impacts function at all levels and increases susceptibility to all major chronic diseases. Insight into the molecular and cellular targets of the ageing process would offer the unprecedented opportunity to ...
Jan, Vijg, Yousin, Suh
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Functional genomics of osteoarthritis
Pharmacogenomics, 2002Functional genomics is a challenging new way to address a complex disease like osteoarthritis on a molecular level. Despite osteoarthritis being ultimately a biochemical problem, mainly characterized by an imbalanced cartilage matrix turnover, a deeper understanding of molecular events within the tissue cells (i.e., the chondrocytes) will provide not ...
Aigner, T. +3 more
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Respiratory Physiology & Neurobiology, 2003
Functional genomics is a systematic and high-throughput effort to analyze the functions of genes and gene products. Functional genomics is divided into gene- and phenotype-driven approaches. Gene-driven approaches to the functional genomics of sleep have demonstrated that transcripts of many genes change as a function of behavioral state.
Miroslaw, Mackiewicz, Allan I, Pack
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Functional genomics is a systematic and high-throughput effort to analyze the functions of genes and gene products. Functional genomics is divided into gene- and phenotype-driven approaches. Gene-driven approaches to the functional genomics of sleep have demonstrated that transcripts of many genes change as a function of behavioral state.
Miroslaw, Mackiewicz, Allan I, Pack
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A Roadmap to functional genomics
Physiological Genomics, 2007In August 2006, the Center for Human Genomics of the Wake Forest University School of Medicine in Winston-Salem, NC, hosted the National Institutes of Health-sponsored Roadmap Course entitled Models and Technologies for Defining Phenotype. Twenty-four biomedical and genomic researchers from throughout the world and with varying degrees of experience ...
Raymond B, Penn +2 more
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Functional genomics in hypertension
Current Opinion in Nephrology and Hypertension, 2006Essential hypertension is a complex polygenetic disease with a major impact on health worldwide. Despite earlier detection of promising candidate genes, only recent advances in genotyping technology and new approaches to examining gene and protein function have provided the tools to unravel the genetic basis of hypertension.In humans, genome-wide scans
Martin W, McBride +3 more
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Functional genomics in the post-genome era
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1998As the biomedical research community enters the post-genome era, studying gene expression patterns and phenotypes in model organisms will be an important part of analyzing the role of genes in human health and disease. New technologies involving DNA chips will improve the ability to evaluate the differential expression of a large number of genes ...
R P, Woychik +5 more
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Computational functional genomics
IEEE Signal Processing Magazine, 2004The exponential growth of the publicly available data has transformed biology into an information rich science that provides new and interesting applications for the machine learning community. In this article, the author presents some specific examples regarding the possibility of representing biological data in a machine-learning framework as well as
Mike P. Liang +4 more
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Functional genomic methodologies
2006The ability to form tenable hypotheses regarding the neurobiological basis of normative functions as well as mechanisms underlying neurodegenerative and neuropsychiatric disorders is often limited by the highly complex brain circuitry and the cellular and molecular mosaics therein.
Stephen D, Ginsberg, Károly, Mirnics
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