Results 211 to 220 of about 400,284 (267)

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review. [PDF]

Am J Med Genet B Neuropsychiatr Genet
Porras LM, Rodríguez-Lausell I, Iglesias-Maldonado G, Tuliao EVF, Martínez G, Leveque C, Tobon J, Eloy R, Belangero S, Bulik CM, Loureiro CM, Carvalho CM, Ota V, Rovaris DL, Storch EA, Vacuan EMT, Velasquez MM, Latin American Genomics Consortium, Santoro ML, Nicolini H, Atkinson EG, Montalvo-Ortiz JL, Giusti-Rodríguez P.   +22 more
europepmc   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Time-resolved functional genomics using deep learning reveals global hierarchical control of autophagy. [PDF]

Nat Cell Biol
Chica N, Andersen AN, Orellana-Muñoz S, Garcia I, P AN, Nakken S, Ayuda-Durán P, Håkensbakken L, Schultz SW, Rødningen E, Putnam CD, Zucknick M, Rusten TE, Enserink JM.   +13 more
europepmc   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

CRISPR-based functional genomics tools in vertebrate models. [PDF]

Exp Mol Med
Varshney GK, Burgess SM.
europepmc   +1 more source

Telomere-to-telomere genome assembly and comprehensive mutation library facilitate bitter gourd breeding and functional genomics research. [PDF]

Plant Commun
Zhang Y, Wang X, Wang Y, Niu Y, Han X, Tan J, Ma X, Zhang Q, Liu J, Zhang Z, Gao W, Liang W, Li L, Liu Z, Zhang X, He H, Yang Y, Yu R.   +17 more
europepmc   +1 more source

EucaMOD: a comprehensive multi-omics database for functional genomics research and molecular breeding of fast-growing eucalyptus trees. [PDF]

Plant J
Li M, Cao Y, Wu W, Mo Y, Wang J, Geng X, Xu J, Fei Y, Su G, Hu H, Li K, Ni J, Xu ZF.   +12 more
europepmc   +1 more source

Publisher Correction: Multimodal cell maps as a foundation for structural and functional genomics. [PDF]

Nature
Schaffer LV, Hu M, Qian G, Moon KM, Pal A, Soni N, Latham AP, Pontano Vaites L, Tsai D, Mattson NM, Licon K, Bachelder R, Cesnik A, Gaur I, Le T, Leineweber W, Palar A, Pulido E, Qin Y, Zhao X, Churas C, Lenkiewicz J, Chen J, Ono K, Pratt D, Zage P, Echeverria I, Sali A, Harper JW, Gygi SP, Foster LJ, Huttlin EL, Lundberg E, Ideker T.   +33 more
europepmc   +1 more source

Decoding the mystery: AI-assisted bioinformatics and functional genomics technologies in medicinal plants. [PDF]

Front Plant Sci
Song C, Sabir IA, Zhao W, Cao Y.
europepmc   +1 more source