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Functional genomics in the post-genome era
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1998As the biomedical research community enters the post-genome era, studying gene expression patterns and phenotypes in model organisms will be an important part of analyzing the role of genes in human health and disease. New technologies involving DNA chips will improve the ability to evaluate the differential expression of a large number of genes ...
R P, Woychik +5 more
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Functional genomic methodologies
2006The ability to form tenable hypotheses regarding the neurobiological basis of normative functions as well as mechanisms underlying neurodegenerative and neuropsychiatric disorders is often limited by the highly complex brain circuitry and the cellular and molecular mosaics therein.
Stephen D, Ginsberg, Károly, Mirnics
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Science, 2001
The recent flood of sequence data and the vision of a complete model of life has created new challenges in biology. First, to find the genes and determine or predict their structures and functions. Then, to understand their biological roles and model the complete cell or organism in silico.
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The recent flood of sequence data and the vision of a complete model of life has created new challenges in biology. First, to find the genes and determine or predict their structures and functions. Then, to understand their biological roles and model the complete cell or organism in silico.
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Naturwissenschaften, 2002
Functional genome analysis of plants has entered the high-throughput stage. The complete genome information from key species such as Arabidopsis thaliana and rice is now available and will further boost the application of a range of new technologies to functional plant gene analysis.
Holtorf, Hauke +2 more
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Functional genome analysis of plants has entered the high-throughput stage. The complete genome information from key species such as Arabidopsis thaliana and rice is now available and will further boost the application of a range of new technologies to functional plant gene analysis.
Holtorf, Hauke +2 more
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Functional genomics of fibroblasts
Current Opinion in Rheumatology, 2004Successful analysis of the pathophysiology of rheumatoid arthritis requires the functional understanding of interactions between different cell types and the cell matrix, intracellular signaling pathways, as well as between cartilage, bone, and synovium in rheumatoid arthritis. During the review period, molecular biology has provided and used a growing
Elena, Neumann +3 more
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Science, 1999
Nucleotide sequencing of the Arabidopsis genome is nearing completion, sequencing of the rice genome has begun, and large amounts of expressed sequence tag information are being obtained for many other plants. There are many opportunities to use this wealth of sequence information to accelerate progress toward a ...
C, Somerville, S, Somerville
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Nucleotide sequencing of the Arabidopsis genome is nearing completion, sequencing of the rice genome has begun, and large amounts of expressed sequence tag information are being obtained for many other plants. There are many opportunities to use this wealth of sequence information to accelerate progress toward a ...
C, Somerville, S, Somerville
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Annual Review of Plant Biology, 2003
Plant systems utilize a diverse array of cytochrome P450 monooxygenases (P450s) in their biosynthetic and detoxicative pathways. Those P450s in biosynthetic pathways play critical roles in the synthesis of lignins, UV protectants, pigments, defense compounds, fatty acids, hormones, and signaling molecules.
Mary A, Schuler +1 more
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Plant systems utilize a diverse array of cytochrome P450 monooxygenases (P450s) in their biosynthetic and detoxicative pathways. Those P450s in biosynthetic pathways play critical roles in the synthesis of lignins, UV protectants, pigments, defense compounds, fatty acids, hormones, and signaling molecules.
Mary A, Schuler +1 more
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Functional genomics in the mouse
Functional & Integrative Genomics, 2002The mouse is the premier genetic model organism for the study of human disease and development. With the recent advances in sequencing of the human and mouse genomes, there is strong interest now in large-scale approaches to decipher the function of mouse genes using various mutagenesis technologies.
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Functional genomics of trypanosomatids
Parasite Immunology, 2012SummaryThe decoding of the Tritryp reference genomes nearly 7 years ago provided a first peek into the biology of pathogenic trypanosomatids and a blueprint that has paved the way for genome‐wide studies. Although 60–70% of the predicted protein coding genes in Trypanosoma brucei, Trypanosoma cruzi and Leishmania major remain unannotated, the ...
J, Choi, N M, El-Sayed
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Current Opinion in Genetics & Development, 2008
Cancer genomics has focused on the discovery of genetic mutations and chromosomal structural rearrangements that either increase susceptibility to cancer or support the cancer phenotype. Though each individual mutation may induce specific cancer phenotypes, it is the interaction of the functional changes in transcription and proteins that give the ...
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Cancer genomics has focused on the discovery of genetic mutations and chromosomal structural rearrangements that either increase susceptibility to cancer or support the cancer phenotype. Though each individual mutation may induce specific cancer phenotypes, it is the interaction of the functional changes in transcription and proteins that give the ...
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