Results 61 to 70 of about 3,788,624 (254)

Integrating sequence, evolution and functional genomics in regulatory genomics. [PDF]

, 2009
With genome analysis expanding from the study of genes to the study of gene regulation, 'regulatory genomics' utilizes sequence information, evolution and functional genomics measurements to unravel how regulatory information is encoded in the genome ...
Brazma, A., Helden, J., Van, Vingron, Martin, Manke, Thomas, Palin, Kimmo, Coulson, Richard, Sand, Olivier, Manke, T., Coulson, R., Brazma, Alvis, Palin, K., Ukkonen, E., Ukkonen, Esko, van Helden, Jacques, Vingron, M., Sand, O.   +15 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Functional Genomics of Wood Quality and Properties

, 2003
Genomics promises to enrich the investigations of biology and biochemistry. Current advancements in genomics have major implications for genetic improvement in animals, plants, and microorganisms, and for our understanding of cell growth, development ...
Tang, Wei,Luo,Xiaoyan,Nelson,Aaron,Collver,Hilary,Kinken, NC DOCKS at East Carolina University   +1 more
core   +2 more sources

A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency

BMC Genomics
Genome-wide CRISPR sgRNA libraries have emerged as transformative tools to systematically probe gene function. While these libraries have been iterated over time to be more efficient, their large size limits their use in some applications.
Sebastian Lukasiak, Alex Kalinka, Nikhil Gupta, Angelos Papadopoulos, Khalid Saeed, Ultan McDermott, Gregory James Hannon, Douglas Ross-Thriepland, David Walter   +8 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Two iPSC lines with frameshift mutations in

Stem Cell Research
CRISPR/Cas9 was used to introduce two different FTSJ1 frameshift mutations into an existing human male iPSC line (UMGWi004-B). No additional genomic or chromosomal changes were detected.
S. Edwards, J. Rhode, L. Hagenau, M.F. Hossain, T. Sura, A. Tzvetkova, B. Nowack, L.R. Jensen, A.W. Kuss   +8 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Integrative functional genomics.

Genome biology, 2004
A report on the Keystone Symposium 'Biological Discovery Using Diverse High-Throughput Data', Steamboat Springs, USA, 30 March-4 April 2004.
openaire   +4 more sources

Ruminant Functional Genomics

, 2022
The collection of datasets produced or gathered as part of the Ruminant Functional Lab led by Dr Emily Clark at the Roslin Institute.Clark, E; Salavati, M "Ruminant Functional Genomics" (2020) Edinburgh DataVault.
Royal (Dick) School of Veterinary Studies, Clark, Emily, Salavati, Mazdak, Simpson, Colin, Bill and Melinda Gates Foundation, Biotechnology and Biological Sciences Research Council   +5 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source