Results 71 to 80 of about 3,788,624 (254)
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Light on genome function [PDF]
Nature Methods, 2013 Optogenetic tools enable light-mediated control over transcription and epigenetic states in specific endogenous loci of the mammalian genome.
openaire +2 more sources
Functional Genomics for Plant Breeding 3.0
Functional genomics, as a scientific discipline, has significantly transformed the landscape of plant breeding in recent years [...
José Manuel Cruz-Rubio, Fatemeh Maghuly
core +1 more source
Czech Journal of Genetics and Plant Breeding, 2011 A wide range of variability in both Na+ exclusion and salinity tolerance was shown in Triticum dicoccoides and the best performing genotype, from Getit, was identified for further study and for crossing.
Y. SHAVRUKOV +7 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
BMC CancerBackground The high mortality rate of breast cancer and the difficulties associated with therapeutic resistance, especially in cases where targeted treatments are unavailable, make it a serious threat to women's health.
Harshi Gupta +9 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Transcription, genomes, function
Trends in Genetics, 2000 Large-scale studies of mRNA expression have displayed the unusual ability to both challenge traditional biological paradigms and enjoy rapid adoption among a wide range of researchers. The proliferating applications of this technology are poised to exert heavy influence on the very way biologists conceptualize problems and ask questions in the post ...
R J, Cho, M J, Campbell
openaire +2 more sources
Crop Functional Genomics and Biological Breeding
Over the past two decades, the rapid development of functional genomics has gradually clarified the regulatory effects of genotypes on phenotypes [...
Dawei Xue +5 more
core +1 more source
Functional genomics: technological challenges and opportunities
, 1999 Strausberg, Robert L., and M. J. Finley Austin. Functional genomics: technological challenges and opportunities. Physiol. Genomics 1: 25–32, 1999.—In April, the Merck Genome Research Institute and the National Cancer Institute's Cancer Genome Anatomy ...
M. J. FINLEY AUSTIN +1 more
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