Results 91 to 100 of about 3,788,624 (254)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Correction: Fadil et al. Isotope Ratio Outlier Analysis (IROA) for HPLC–TOFMS-Based Metabolomics of Human Urine. Metabolites 2022, 12, 741

Metabolites
It was pointed out to us that we had not followed exactly the IROA TruQuant IQQ Workflow Kit protocol in the experimental part of our work [...]
Fadi Fadil, Claudia Samol, Raffaela S. Berger, Fabian Kellermeier, Wolfram Gronwald, Peter J. Oefner, Katja Dettmer   +6 more
doaj   +1 more source

Intranasal Vaccination With Lipoproteins Confers Protection Against Pneumococcal Colonisation

Frontiers in Immunology, 2018
Streptococcus pneumoniae is endowed with a variety of surface-exposed proteins representing putative vaccine candidates. Lipoproteins are covalently anchored to the cell membrane and highly conserved among pneumococcal serotypes. Here, we evaluated these
Franziska Voß, Thomas P. Kohler, Tanja Meyer, Mohammed R. Abdullah, Fred J. van Opzeeland, Malek Saleh, Stephan Michalik, Saskia van Selm, Frank Schmidt, Frank Schmidt, Marien I. de Jonge, Sven Hammerschmidt   +11 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Plant functional genomics: protein diversity in an OsCHLH knockout rice mutant by a single gene mutation

, 2004
2
안진흥
core  

Recent progress in development of Tnt1 functional genomics platform for medicago truncatula and Lotus japonicus in Bulgaria

, 2011
Legumes, as protein-rich crops, are widely used for human food, animal feed and vegetable oil production. Over the past decade, two legume species, Medicago truncatula and Lotus japonicus, have been adopted as model legumes for genomics and physiological
Goormachtig, SofieWE098010008409270000-0001-6195-9889F49A9C58-F0ED-11E1-A9DE-61C894A0A6B4, Goormachtig, Sofie, Ratet, Pascal, Tom Van Hautegem, Van Hautegem, Tom, Valya Vassileva, Sofie Goormachtig, Van Hautegem, TomUGent0020032786558020006774209770936492040000-0003-3173-2477031D280E-F0EE-11E1-A9DE-61C894A0A6B4, Vassileva, Valya, Iantcheva, Anelia, Revalska, Miglena, Miglena Revalska, Anelia Iantcheva, Pascal Ratet   +13 more
core   +1 more source

Structure-based inference of molecular functions of proteins of unknown function from Berkeley Structural Genomics Center [PDF]

, 2007
Advances in sequence genomics have resulted in an accumulation of a huge number of protein sequences derived from genome sequences. However, the functions of a large portion of them cannot be inferred based on the current methods of sequence homology ...
Hou, Jingtong, Kim, Sung-Hou, Das, Debanu, Kim, Rosalind, Shin, Dong Hae, Chandonia, John-Marc, Choi, In-Geol, 신동해   +7 more
core   +1 more source

Functional Genomics in Health and Disease

, 2021
Functional genomics applied in clinical disease diagnosis and prognosis allow the achievement of the progress in all aspects of biology in health and disease [...
Cornelia Braicu
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source