Results 91 to 100 of about 2,581,993 (313)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Crown Ethers and Analogs: Updates from the Chemistry of the Functional Groups

, 2010
This second book in the Patai Updates "mini series" relates to four chapters from the original Supplement E and to Supplement C. Coverage includes complexation of aryldiazonium ions by polyethers, complexes and selectivity of crown ethers, and structural
Laidler, Dale A., Stoddart, J. Fraser, Toner, John L., Liotta, Charles L., Patai, Saul, VöGtle, Fritz, Goldberg, Israel, Weber, Edwin, Rappoport, Zvi, Bartsch, Richard A.   +9 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Coordination Chemistry and Applications of Nitrilotris(N-Methylenephenoxy)-Metal ComplexesPATAI'S Chemistry of Functional Groups

, 2014
Nitrilotris(N-methylenephenols), commonly called triphenolamines (TPA), are highly modular, tetradentate molecules that effectively coordinate to transition metals and main group elements with podand topology.
ZONTA, CRISTIANO, LICINI, GIULIA MARINA, MBA BLAZQUEZ, MIRIAM   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Weekly dynamics of phytoplankton functional groups under high water level fluctuations in a subtropical reservoir-bay

, 2011
In reservoirs, water level fluctuations strongly influence phytoplankton development. However, studies on the response of phytoplankton in the reservoir-bay to water level fluctuations are very scarce, especially in the highly dynamic reservoir system ...
Wang, Lan, Cai, QH, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China, Cai, Qinghua, Tan, Lu, qhcai@ihb.ac.cn, Xu, Yaoyang, Kong, Linghui, Zhang, Min   +7 more
core  

Appendix A. Functional groups and reefs surveyed.

, 2016
Functional groups and reefs ...
Loïc M. Thibaut (2923992), Hugh P. A. Sweatman (2923995), Sean R. Connolly (203967)   +2 more
core   +1 more source

Aromatic Rings Commonly Used in Medicinal Chemistry: Force Fields Comparison and Interactions With Water Toward the Design of New Chemical Entities

Frontiers in Pharmacology, 2018
The identification of lead compounds usually includes a step of chemical diversity generation. Its rationale may be supported by both qualitative (SAR) and quantitative (QSAR) approaches, offering models of the putative ligand-receptor interactions.
Marcelo D. Polêto, Victor H. Rusu, Bruno I. Grisci, Marcio Dorn, Roberto D. Lins, Hugo Verli   +5 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source