Results 81 to 90 of about 10,695,687 (313)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Lung structural and functional impairments in young children with cystic fibrosis diagnosed following newborn screening - A nationwide observational study. [PDF]

BACKGROUND Non-invasive and sensitive clinical endpoints are needed to monitor onset and progression of early lung disease in children with cystic fibrosis (CF).
Rochat, Isabelle, Blanchon, Sylvain, Latzin, Philipp, Moeller, Alexander, Müller-Suter, D., Salem, Yasmin, Stranzinger, Enno, Müller-Suter, Dominik, Ramsey, Kathryn A, Regamey, Nicolas, Cotting, J., Willers, C., Kieninger, Elisabeth, Willers, Corin, Usemann, Jakob, Ramsey, K.A., Latzin, P., Kuhn, A., Frauchiger, Bettina S, Regamey, N., Korten, Insa, Brabandt, Ben, Salem, Y., Rochat, I., Moeller, A., Blanchon, S., Stranzinger, E., Bauman, G., Brabandt, B., Cotting, Jasna, Korten, I., Bauman, Grzegorz, Frauchiger, B.S., Casaulta, Carmen, Usemann, J., Kieninger, E., Casaulta, C., Kuhn, Alena   +37 more
core   +2 more sources

Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia [PDF]

, 2011
Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ∼1%. Previous studies have implicated synaptic dysfunction in schizophrenia.
Purcell, S.M., Toonen, R.F.G.; id_orcid, Visscher, P M, O'Donovan, M. C., C M Hultman, Lips, Esther S, Holmans, Peter A, Purcell, Shaun, Sullivan, P.F., Holmans, P A, O'Donovan, Michael C., Purcell, S. M., Sullivan, P F, Cornelisse, L N, Visscher, P.M., Posthuma, Danielle, P M Visscher, Smit, August, R F Toonen, Lips, E.S., Min, Josine L, Hultman, C. M., Hultman, Christina, Sullivan, P. F., Verhage, Matthijs, Visscher, Peter M, M Verhage, Verhage, M, Visscher, P. M., Consortium, International Schizophrenia, M C O'Donovan, Purcell, S M, Toonen, R. F., Posthuma, D., null null, P A Holmans, Toonen, R.F.G., Smit, A. B., Smit, A.B., Smit, A B, Min, J. L., O'Donovan, M.C., E S Lips, Min, J L, Holmans, Peter Alan, Hultman, C M, Holmans, P. A., L N Cornelisse, Toonen, R F, O'Donovan, Michael Conlon, P F Sullivan, Cornelisse, L.N., Purcell, Shaun M., Holmans, P.A., Verhage, M., O'Donovan, M C, J L Min, D Posthuma, International Schizophrenia Consortium, S M Purcell, Hultman, C. M.,, Min, J.L., Lips, E. S., Cornelisse, L. N., Cornelisse, L Niels, Lips, E S, Sullivan, Patrick, Toonen, Ruud F, Hultman, C., Posthuma, D, A B Smit, Posthuma, D.; id_orcid   +71 more
core   +1 more source

Identity of mass-flowering crops moderates functional trait composition of pollinator communities

, 2023
Context Pollinator declines and functional homogenization of farmland insect communities have been reported. Mass-flowering crops (MFC) can support pollinators by providing floral resources.
Beyer, Nicole; Functional Agrobiodiversity, Department of Crop Sciences, University of Göttingen, Göttingen, Germany, Gabriel, Doreen, Beyer, Nicole, Westphal, Catrin, Kirsch, Felix, Westphal, Catrin; Centre of Biodiversity and Sustainable Land Use (CBL), University of Göttingen, Göttingen, Germany, Kirsch, Felix; Functional Agrobiodiversity, Department of Crop Sciences, University of Göttingen, Göttingen, Germany, Gabriel, Doreen; Institute for Crop and Soil Science, Julius Kühn-Institut (JKI), Braunschweig, Germany   +7 more
core   +1 more source

Phytoplankton assemblages in Lake Orta: has functional structure recovered in one of the largest acidic lakes in the world?

Journal of Limnology, 2016
Lake Orta (Northern Italy) became one of the world’s largest acidic lakes, following industrial pollution, beginning in the late 1920s. Prior to pollution, Lake Orta supported a rich and diversified phytoplankton community dominated by diatoms ...
Giuseppe Morabito
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Trophic links between functional groups of arable plants and beetles are stable at national scale [PDF]

, 2011
1. There is an urgent need to accurately model how environmental change affects the wide-scale functioning of ecosystems, but advances are hindered by a lack of knowledge of how trophic levels are linked across space.
Brooks, D. R., Storkey, J., Jonathan Storkey, Brooks, David R., Suzanne J. Clark, Petit, S., David R. Brooks, Les G. Firbank, Woiwod, I. P., Ian P. Woiwod, Clark, Suzanne J., Firbank, L. G., Woiwod, Ian P., Petit, Sandrine, Storkey, Jonathan, Sandrine Petit, Clark, S. J., Firbank, Les G.   +17 more
core   +1 more source

Function groups in Kleinian groups

Mathematische Annalen, 1992
Function subgroups \(G_ 1\), \(G_ 2\) of any Kleinian group \(G\) are investigated, and some results in \textit{B. Maskit} [Ann. Math. Studies No. 79, 349-367 (1974; Zbl 0305.30021)] are generalized. Theorem 1 shows that any function group is geometrically tame by using the results in \textit{F. Bonahon} [Ann. Math., II. Ser.
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Reductive Cleavage of Secondary Sulfonamides: Converting Terminal Functional Groups into Versatile Synthetic Handles [PDF]

, 2019
Sulfonamides are pervasive in drugs and agrochemicals, yet are typically considered as terminal functional groups rather than synthetic handles. To enable the general late-stage functionalization of secondary sulfonamides, we have developed a mild and ...
Patrick, Fier, Kevin M., Maloney, Suhong, Kim   +2 more
core   +2 more sources