Complex Gastroesophageal Reflux Disease
Gastro Hep Advances, 2022 Gastroesophageal reflux disease (GERD) is the most prevalent gastrointestinal disorder posing diagnostic and therapeutic challenges. Diagnosis should be objectively defined with endoscopy and pH testing, while novel metrics may augment diagnosis for ...
Diana L. Snyder, David A. Katzka
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Current management of proton pump inhibitor-refractory gastroesophageal reflux disease
Фундаментальная и клиническая медицина, 2020 Here we review current concepts in diagnosis and treatment of proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (PPIGERD) which includes an insufficient response to daily PPI 8-week therapy in combination with pathological ...
V. V. Tsukanov +2 more
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Personalized diagnosis of patients with gastroesophageal reflux disease using 24-hour pH-impedance testing and high-resolution esophageal manometry [PDF]
Терапевтический архивAim. To determine the phenotypic variants of patients with symptoms of gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), hypersensitive esophagus (HSE), functional heartburn (FH) using 24-hour pH-impedance testing and high ...
Igor V. Maev +5 more
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Gastrointestinal functional disorders can benefit from the use of medical devices made of substances
Frontiers in Drug Safety and Regulation, 2023 Medical devices made of substances (MDMS) have recently gained great popularity in several specialties of internal medicine, including gastroenterology. In the last decades this discipline has known relevant advances in the cure of severe diseases, such ...
Vincenzo Savarino +6 more
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Current advances in the diagnosis and management of gastroesophageal reflux disease
Tzu Chi Medical Journal, 2022 Gastroesophageal reflux disease (GERD) is very common and defined as troublesome symptoms owing to excessive acid reflux. The spectrum of GERD is broad, including not only erosive esophagitis and Barrett's esophagus but also nonerosive reflux disease ...
Shu-Wei Liang +8 more
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Frontiers in Immunology, 2023 IntroductionHeartburn pathogenesis in GERD remains incompletely understood. We aimed to identify differences in the immune cell signature and sensory mucosal markers between reflux phenotypes and healthy asymptomatic subjects.MethodsThirty-seven patients
Ahsen Ustaoglu +10 more
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Distinction between patients with non-erosive reflux disease and functional heartburn. [PDF]
Ann Gastroenterol, 2013 Giacchino M, Savarino V, Savarino E.
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Histomorphological differentiation of non-erosive reflux disease and functional heartburn in patients with PPI-refractory heartburn [PDF]
Alimentary Pharmacology & Therapeutics, 2013 Proton pump inhibitor (PPI)-refractory heartburn may be due to persistent gastro-oesophageal reflux, oesophageal hypersensitivity or functional heartburn (FH). The differentiation between non-erosive reflux disease (NERD) and FH may be very difficult. However, this differentiation is important for appropriate therapeutic management.
A, Kandulski +6 more
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Functional heartburn: the stimulus, the pain, and the brain [PDF]
Gut, 2002 Functional heartburn is a common disorder and appears to be composed of several distinct subgroups. Identifying the different subgroups based on clinical history only is not achievable at present. The mechanisms responsible for pain, clinical characteristics, and the optimal therapeutic approach remain poorly understood.
R, Fass, G, Tougas
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Functional heartburn: An underrecognized cause of PPI-refractory symptoms
Cleveland Clinic Journal of Medicine, 2019 Functional heartburn--persistent symptoms of esophageal reflux with no objective evidence of gastroesophageal reflux disease (GERD)--is the most common cause of failure of proton pump inhibitor (PPI) therapy, but it is often overlooked by internists and gastroenterologists.
Scott Gabbard, Sonya Vijayvargiya
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