Results 171 to 180 of about 107,051 (305)

Mosaic Matters: A Transcriptomic Window into FCDII Epileptogenesis. [PDF]

Epilepsy Curr
Nguyen LH.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Subject of Functional Foods: Accounts of Using Foods Containing Phytosterols [PDF]

This paper explores the notion of the late modern or reflexive subject, for whom consumption, rationality, autonomy and a reflexive attitude to risk are said to be constitutive.
Kate Weiner
core  

Patch type nucleotide sequence identities between genomes from many different species facilitate illegitimate recombination. [PDF]

Sci Rep
Weber S, Ramirez CM, Doerfler W.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Constructing entrepreneurial identities: the case of entrepreneurial dyads

, 2010
This thesis investigates the processes of identity construction and identity work in entrepreneurial dyads. Entrepreneurial dyads are defined as two-person teams, in which members are bound both by a strong social tie and by a common commitment to start ...
Bisignano, A
core  

Evolutionary and taxonomic insights into the genomic divergence of cowpea mild mottle virus: rapid evolution in replication-associated protein gene, but strong negative selection on coat protein gene. [PDF]

J Gen Virol
Silva BA, Silva JMF, Kauffmann CM, Cárdenas SBDS, Queiroz PS, Batista AMDV, Mota HBDS, Blawid R, Freitas DMS, Inoue-Nagata AK, Nagata T.   +10 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

On Relationships Between Ostrowski, Trapezoidal and Chebychev Identities and Inequalities

, 2001
This article investigates the relationship between the Ostrowski, Trapezoidal and Chebychev functional identities. It demonstrates how one may be obtained from the other thorugh transformations. The relationships between bounds on the functionals is also
Cerone, Pietro
core  

Disability Studies and Disability Evaluation in Healthcare-Themes and Challenges Moving Forward. [PDF]

Healthcare (Basel)
Harley DA, Chao SY.
europepmc   +1 more source