Results 91 to 100 of about 2,198,997 (290)

On universally integrable functions [PDF]

Proceedings of the American Mathematical Society, 1955
Let X be an abstract space and 21 be a Boolean algebra of sets E in X. Let p be a finite collection of disjoint sets { Ek } in W which partition X. The partitions p form a lattice [1 ] if we define p
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Multi‐Scale MXene/Silver Nanowire Composite Foams with Double Conductive Networks for Multifunctional Integration

Advanced Science
With the onset of the 5G era, wearable flexible electronic devices have developed rapidly and gradually entered the daily life of people. However, the vast majority of research focuses on the integration of functions and performance improvement, while ...
Chenhui Xu, Zhihui Li, Tianyi Hang, Yiming Chen, Tianlong He, Xiping Li, Jiajia Zheng, Zhiyi Wu   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The contributions of resting-state functional-MRI studies to our understanding of male patients with obstructive sleep apnea: a systematic review

Frontiers in Neurology
ObjectivesObstructive sleep apnea (OSA) is a condition marked by the recurrent partial or complete obstruction of the upper airway during sleep. This leads to intermittent pauses in breathing, fragmented sleep, and frequent awakenings throughout the ...
Ruoxi Yu, Yan Li, Kangqing Zhao, Fangfang Fan   +3 more
doaj   +1 more source

Economic Reasoning and Interaction in Socially Extended Market Institutions

Frontiers in Psychology, 2019
An important part of what it means for agents to be situated in the everyday world of human affairs includes their engagement with economic practices.
Shaun Gallagher, Shaun Gallagher, Antonio Mastrogiorgio, Enrico Petracca   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

FIAR: An R Package for Analyzing Functional Integration in the Brain

Journal of Statistical Software, 2011
Functional integration in the brain refers to distributed interactions among functionally segregated regions. Investigation of effective connectivity in brain networks, i.e, the directed causal influence that one brain region exerts over another region ...
Yves Rosseel, Bjorn Roelstraete
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source