Results 61 to 70 of about 37,182 (262)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

TRANSCRANIAL DIRECT CURRENT STIMULATION AND MANUAL ASYMMETRIES: THE EFFECT OF THE STIMULATION ON THE MANUAL DEXTERITY

Journal of Physical Education, 2017
The aim of this study was to evaluate the effect of transcranial direct-current stimulation (tDCS) on the primary motor cortex (M1) in the manual performance asymmetries in a manual dexterity tasks.
Mayndra Giusti Salvador, Herbert Ugrinowitsch, Marco Aurélio Romano-Silva, Débora Marques de Miranda, Tércio Apolinário-Souza, Guilherme Menezes Lage   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Performance comparison between right-handers and left-handers in a Brazilian sample of the Developmental Neuropsychological Assessment

Estudos de Psicologia (Campinas)
Studies that investigate handedness are performed in order to relate hemispheric specialization and cognitive performance. The aim of study was compare the neuropsychological performance between right-handed and left-handed children with ages from five ...
Andrea ASSIS, Neander ABREU, Maria da Conceição Cedraz PRINZ, Nayara ARGOLLO, Tatiane MIRANDA   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Hemispheric speech lateralisation in the developing brain is related to motor praxis ability

Developmental Cognitive Neuroscience, 2016
Commonly displayed functional asymmetries such as hand dominance and hemispheric speech lateralisation are well researched in adults. However there is debate about when such functions become lateralised in the typically developing brain.
Jessica C. Hodgson, Rebecca J. Hirst, John M. Hudson   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Diffusion tensor magnetic resonance imaging for hand and foot fibers location at the corona radiata: comparison with two lesion studies

Frontiers in Human Neuroscience, 2014
The corticospinal tract is the motor pathway in the human brain, and corona radiata is an important location to diagnose stroke. We detected hand and foot motor fiber tracts in the corona radiata to investigate accurate locations using diffusion tensor ...
Dong-Hoon eLee, Cheolpyo eHong, Bong-Soo eHan   +2 more
doaj   +1 more source