Results 151 to 160 of about 731,823 (276)

Middle-age healthcare spending and utilization at the intersection of comorbidities, functional limitation, and race/ethnicity. [PDF]

Innov Aging
Toseef MU, Sultana S, Samuel P, Tarraf W.   +3 more
europepmc   +1 more source

Effects of Walking as Physical Exercise on Functional Limitation through Pain in Patients with Fibromyalgia-How Does Catastrophic Thinking Contribute? [PDF]

Int J Environ Res Public Health, 2022
Catalá P, Peñacoba C, López-Roig S, Pastor-Mira MA.   +3 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Psychometric properties of the Arabic version of the Jaw Functional Limitation Scale (JFLS-Ar) in patients with temporomandibular disorders. [PDF]

BMC Oral Health
Elkhawaga H, Gamiel A, Badr M, Haridy DA, Khalil AA.   +4 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Individual and combined associations of modifiable metabolic health and lifestyle with low back pain, neck pain, and functional limitation: evidence from a nationally cross-sectional study. [PDF]

BMC Public Health
Xie C, Li Q, Xin J, Jiang X, He Q, Bian W, Yu D, Lin Y, Yao Z.   +8 more
europepmc   +1 more source

Persisting and New Onset Symptomatology and Determinants of Functional Limitation of Post Acute COVID-19 Syndrome Cases- A Study from a Northern District of Kerala. [PDF]

Indian J Community Med, 2023
Chathoth AT, Anaswara N, Meethal AC, Vasudevan J, Gopal PV.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evaluation of mandibular functional limitation in patients with temporomandibular joint disorders and the relationship with other psychosocial factors. [PDF]

PLoS One
Hoa NN, Do T, Thai Binh T, Thanh Dong T, Minh Quyen TT, Hoang VH.   +5 more
europepmc   +1 more source