Results 41 to 50 of about 728,696 (332)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Abnormal Granger causal connectivity based on altered gray matter volume and associated neurotransmitters of adolescents with internet gaming disorder revealed by a multimodal neuroimaging study

Developmental Cognitive Neuroscience
Although prior studies have revealed alterations in gray matter volume (GMV) among individuals with internet gaming disorder (IGD). The brain's multifaceted functions hinge crucially on the intricate connections and communication among distinct regions ...
Xiaoyu Niu, Mengzhe Zhang, Xinyu Gao, Jinghan Dang, Jieping Sun, Qiuying Tao, Yan Lang, Weijian Wang, Yarui Wei, Shaoqiang Han, Huayan Xu, Yingkun Guo, Jingliang Cheng, Yong Zhang   +13 more
doaj   +1 more source

Weight Status Modulated Brain Regional Homogeneity in Long-Term Male Smokers

Frontiers in Psychiatry, 2022
BackgroundTobacco smoking and being overweight could lead to adverse health effects, which remain an important public health problem worldwide. Research indicates that overlapping pathophysiology may contribute to tobacco addiction and being overweight ...
Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Jingli Chen, Jingli Chen, Jingli Chen, Jingli Chen, Jingli Chen, Jingli Chen, Jingli Chen, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang   +69 more
doaj   +1 more source

A Pneumatically Actuated Manipulandum for Neuromotor Control Research [PDF]

, 2002
Functional magnetic resonance imaging (fMRI) techniques have great potential for identifying which neural structures are involved in the control of goal-directed reaching movements.
Ropella, Kristina M., Scheidt, Robert A., Suminski, Aaron J   +2 more
core   +1 more source

Central Executive Dysfunction and Deferred Prefrontal Processing in Veterans with Gulf War Illness. [PDF]

, 2013
Gulf War Illness is associated with toxic exposure to cholinergic disruptive chemicals. The cholinergic system has been shown to mediate the central executive of working memory (WM).
Bennett, Ilana J, Brigante, Ryan M, Haley, Robert W, Hubbard, Nicholas A, Hutchison, Joanna L, Motes, Michael A, Rypma, Bart, Shokri-Kojori, Ehsan   +7 more
core   +2 more sources

Functional Diffusion Magnetic Resonance Imaging

, 2018
Functional diffusion magnetic resonance imaging (fDMRI) is a noninvasive technique that allows elucidating physiological and anatomical changes at a microscopic scale by detection of water molecular displacements in tissue structures. These displacements likely reflect microstructural changes associated with neuronal or glial cells activation.
Rocha Oliveira, Rita Maria, Guadilla, Irene, López-Larrubia, Pilar   +2 more
openaire   +3 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

MRI-guided cell membrane-camouflaged bimetallic coordination nanoplatform for combined tumor phototherapy

Materials Today Bio
Nanotechnology for tumor diagnosis and optical therapy has attracted widespread interest due to its low toxicity and convenience but is severely limited due to uncontrollable tumor targeting.
Mengyang Zhou, Yifei Wang, Yaning Xia, Yinhua Li, Jianfeng Bao, Yong Zhang, Jingliang Cheng, Yupeng Shi   +7 more
doaj   +1 more source

Neuroimaging techniques in epilepsy [PDF]

, 2010
Objective: To review state-of-the-art neuroimaging modalities in epilepsy and their clinical applications. Data sources and study selection: PubMed literature searches to March 2010, using the following key words: 'epilepsy', 'positron emission ...
Ho, WY, Hung, KN, Lai, V, Mak, HKF, Yung, AWY   +4 more
core  

Models of atypical development must also be models of normal development [PDF]

, 2002
Functional magnetic resonance imaging studies of developmental disorders and normal cognition that include children are becoming increasingly common and represent part of a newly expanding field of developmental cognitive neuroscience. These studies have
Mareschal, D, Westermann, G
core   +1 more source