Results 41 to 50 of about 388,478 (263)

fMRI reveals neural activity overlap between adult and infant pain

eLife, 2015
Limited understanding of infant pain has led to its lack of recognition in clinical practice. While the network of brain regions that encode the affective and sensory aspects of adult pain are well described, the brain structures involved in infant ...
Sezgi Goksan, Caroline Hartley, Faith Emery, Naomi Cockrill, Ravi Poorun, Fiona Moultrie, Richard Rogers, Jon Campbell, Michael Sanders, Eleri Adams, Stuart Clare, Mark Jenkinson, Irene Tracey, Rebeccah Slater   +13 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Alterations in static and dynamic regional homogeneity in mesial temporal lobe epilepsy with and without initial precipitating injury

Frontiers in Neuroscience, 2023
ObjectivesInitial precipitating injury (IPI) such as febrile convulsion and intracranial infection will increase the susceptibility to epilepsy. It is still unknown if the functional deficits differ between mesial temporal lobe epilepsy with IPI (mTLE ...
Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Chengru Song, Chengru Song, Chengru Song, Chengru Song, Chengru Song, Chengru Song, Chengru Song, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Xin Wang, Xin Wang, Xin Wang, Xin Wang, Xin Wang, Xin Wang, Xin Wang, Yajun Lian, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Yan Zhang, Yan Zhang, Yan Zhang, Yan Zhang, Yan Zhang, Yan Zhang, Yan Zhang   +70 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Meta-analysis of structural and functional brain alterations in internet gaming disorder

Frontiers in Psychiatry, 2022
BackgroundMany neuroimaging studies have reported abnormalities in brain structure and function in internet gaming disorder (IGD). However, the findings were divergent.
Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Weijian Wang, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Yarui Wei, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang   +79 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

The recent history of afferent stimulation modulates corticospinal excitability

NeuroImage, 2022
Background: Transcranial magnetic stimulation (TMS) is widely used to probe corticospinal excitability and fast sensorimotor integration in the primary motor hand area (M1-HAND).
Marie Trolle Bonnesen, Søren Asp Fuglsang, Hartwig Roman Siebner, Lasse Christiansen   +3 more
doaj   +1 more source

FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee, Jeffrey Lambe, Scott Johnson, Akua Abrah, Jennifer Bullen, Jeffrey A. Cohen, Tatchaporn Ongphichetmetha, Amy Kunchok   +7 more
wiley   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source