Results 81 to 90 of about 6,916,372 (302)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Real-time imaging of the medullary circuitry involved in the generation of spontaneous muscle sympathetic nerve activity in awake human subjects [PDF]

, 2008
In order to understand the central neural processes involved in blood pressure regulation we recorded muscle sympathetic nerve activity (MSNA) via a tungsten microelectrode in the common peroneal nerve while performing functional Magnetic Resonance ...
Vaughan Macefield, Luke Henderson
core  

The multisensory attentional consequences of tool use : a functional magnetic resonance imaging study [PDF]

, 2008
Background: Tool use in humans requires that multisensory information is integrated across different locations, from objects seen to be distant from the hand, but felt indirectly at the hand via the tool.
Calvert, GA, Clare E Mackay, Peter C Hansen, Holmes, Nicholas P., Spence, Charles, Calvert, Gemma A., Mackay, Clare E., Holmes, NP, Charles Spence, Gemma A Calvert, Spence, C, Nicholas P Holmes, Hansen, Peter C., MacKay, CE, Calvert, Gemma, Hansen, Peter; id_orcid, Mackay Clare E., Hansen Peter C., Spence Charles, Calvert Gemma A., Holmes Nicholas P.   +20 more
core   +2 more sources

Theta Activity in the Left Dorsal Premotor Cortex During Action Re-Evaluation and Motor Reprogramming

Frontiers in Human Neuroscience, 2018
The ability to rapidly adjust our actions to changes in the environment is a key function of human motor control. Previous work implicated the dorsal premotor cortex (dPMC) in the up-dating of action plans based on environmental cues.
Giovanni Pellegrino, Giovanni Pellegrino, Leo Tomasevic, Damian Marc Herz, Damian Marc Herz, Kit Melissa Larsen, Kit Melissa Larsen, Hartwig Roman Siebner, Hartwig Roman Siebner   +8 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Functional nanoparticles for magnetic resonance imaging

WIREs Nanomedicine and Nanobiotechnology, 2016
Nanoparticle‐based magnetic resonance imaging (MRI) contrast agents have received much attention over the past decade. By virtue of a high payload of magnetic moieties, enhanced accumulation at disease sites, and a large surface area for additional modification with targeting ligands, nanoparticle‐based contrast agents offer promising new platforms to ...
Xinpei, Mao, Jiadi, Xu, Honggang, Cui
openaire   +3 more sources

Adaptive Gaussian Markov Random Fields with Applications in Human Brain Mapping [PDF]

, 2005
Functional magnetic resonance imaging (fMRI) has become the standard technology in human brain mapping. Analyses of the massive spatio-temporal fMRI data sets often focus on parametric or nonparametric modeling of the temporal component, while spatial ...
Brezger, Andreas, Fahrmeir, Ludwig, Hennerfeind, Andrea   +2 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Micro-magnetic resonance imaging study of live quail embryos during embryonic development [PDF]

, 2011
Eggs containing live Japanese quail embryos were imaged using micro-magnetic resonance imaging (μMRI) at 24-h intervals from Day 0 to 8, the period during which the main body axis is being laid down and organogenesis is taking place.
Welten, Monique, Tickle, Cheryll, Baggott, Glenn, Glenn Baggott, Morrison, Fiona, Suzanne Duce, Fiona Morrison, Cheryll Tickle, Monique Welten, Welten, M., Duce, Suzanne, Baggott, Glenn K., Morrison, F., Tickle, C., Duce, S.   +14 more
core   +1 more source