Results 71 to 80 of about 6,916,372 (302)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Multimodal Imaging Findings of Cerebral Amyloid Angiopathy Related Inflammation With Unusual Clinical Manifestation: A Case Report [PDF]

, 2023
Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare encephalopathy characterized by the coexistence of a perivascular inflammatory reaction in patients with cerebral amyloid angiopathy.
서상현, 유영훈, 이재훈, 주비오, 유한수, 안성준, 박미나   +6 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Cardiovascular magnetic resonance activity in the United Kingdom: a survey on behalf of the british society of cardiovascular magnetic resonance [PDF]

, 2011
<p>Background: The indications, complexity and capabilities of cardiovascular magnetic resonance (CMR) have rapidly expanded. Whether actual service provision and training have developed in parallel is unknown.</p> <p>Methods: We ...
J. Moon (6723125), Pennell, D.J., S. Neubauer (1410220), Payne, J., J. Payne (2409088), Antony Renjith, Dargie, HJ, G. P. McCann (7591697), Antony, R, Hawkins, N.M., Payne John, C. Berry (7606274), Dargie, H.J., Renjith Antony, Nathaniel M Hawkins, Henry J Dargie, James Moon, Petrie Mark C, S. Daghem (7606259), Gerry P. McCann (7241615), Moon, J., Daghem, M., Pennell, DJ, Pennell Dudley J, Mark C Petrie, H. J. Dargie (7606265), Neubauer Stefan, Marwa Daghem, Antony, R., Gerry P McCann, R. Antony (7606253), McCann, GP, M. Daghem (7606256), Petrie, M.C., Moon James, Hawkins, NM, Safa Daghem, Daghem Marwa, Berry Colin, Colin Berry, D. J. Pennell (7606268), Dargie Henry J, McCann, G.P., Daghem, S, Payne, J, Neubauer, S., Hawkins Nathaniel M, Daghem, M, Daghem, S., Petrie, MC, McCann Gerry P, N. M. Hawkins (7606271), Moon, J, Dudley J Pennell, Berry, C, Berry, C., Neubauer, S, John Payne, M. C. Petrie (7606262), Daghem Safa, Stefan Neubauer   +60 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

High-resolution mapping of substantia nigra in Parkinson’s disease using 7 tesla magnetic resonance imaging

npj Parkinson's Disease
Parkinson’s disease causes a progressive loss of dopaminergic neurons and iron accumulation in the substantia nigra pars compacta. Using ultra-high field magnetic resonance imaging (MRI) at 7 tesla in 43 Parkinson’s patients and 24 healthy controls, we ...
Christopher F. Madelung, Annemette Løkkegaard, Søren A. Fuglsang, Marta M. Marques, Vincent O. Boer, Kristoffer H. Madsen, Anne-Mette Hejl, David Meder, Hartwig R. Siebner   +8 more
doaj   +1 more source

A clinical-radiomics combined model based on carotid atherosclerotic plaque for prediction of ischemic stroke

Frontiers in Neurology
ObjectivesTo accurately predict the risk of ischemic stroke, we established a radiomics model of carotid atherosclerotic plaque-based high-resolution vessel wall magnetic resonance imaging (HR-VWMRI) and combined it with clinical indicators.Materials and
Na Han, Na Han, Na Han, Wanjun Hu, Wanjun Hu, Wanjun Hu, Yurong Ma, Yurong Ma, Yu Zheng, Yu Zheng, Yu Zheng, Songhong Yue, Songhong Yue, Songhong Yue, Laiyang Ma, Laiyang Ma, Laiyang Ma, Jie Li, Jie Li, Jing Zhang, Jing Zhang   +20 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Thalamocortical Connectivity and Microstructural Changes in Congenital and Late Blindness

Neural Plasticity, 2017
There is ample evidence that the occipital cortex of congenitally blind individuals processes nonvisual information. It remains a debate whether the cross-modal activation of the occipital cortex is mediated through the modulation of preexisting ...
N. H. Reislev, T. B. Dyrby, H. R. Siebner, H. Lundell, M. Ptito, R. Kupers   +5 more
doaj   +1 more source