Results 121 to 130 of about 6,299,044 (286)

Subchronic memantine induced concurrent functional disconnectivity and altered ultra-structural tissue integrity in the rodent brain: revealed by multimodal MRI [PDF]

, 2013
Background An effective NMDA antagonist imaging model may find key utility in advancing schizophrenia drug discovery research. We investigated effects of subchronic treatment with the NMDA antagonist memantine by using behavioural observation and ...
Ver Donck, L., Van der Linden, A, Giugliano, M., Sijbers, J., Sijbers, J, Wuyts, K, Sekar, S, Couto, J, Ver Donck, L, Willems, R, Mackie, C., Steckler, T, Couto, J., Van Der Linden, A., Willems, R., Jonckers, Elisabeth, Jonckers, E., Veraart, J, Van Auderkerke, J, Steckler, T., Giugliano, M, Veraart, J., Wuyts, K., Mackie, C, Van Audekerke, J., Dedeurwaerdere, S., Verhoye, M, Verhoye, M., De Deurwaerdere, S, Sekar, S.   +29 more
core   +1 more source

Association of Nasal Anatomy, Airflow, and Surgery With Olfactory Outcomes: A State‐of‐the‐Art Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Olfactory function is influenced by nasal airflow dynamics and anatomical variations within the nasal cavity. This narrative review evaluates how nasal anatomy and airflow relate to olfactory outcomes, with a particular focus on olfactory changes following functional nasal surgery. Data Sources PubMed.
Joshua Ferreira, Alfonso Luca Pendolino, Riccardo Pappalardo, Peter J. Andrews   +3 more
wiley   +1 more source

Magnetic Resonance Imaging of Neuronal Function in the Spinal Cord: Spinal fMRI [PDF]

Clinical Medicine & Research, 2005
A review of the current literature on magnetic resonance imaging of neuronal function in the spinal cord (spinal fMRI) is presented. The unique challenges of spinal fMRI are identified as being the small cross-sectional dimensions of the spinal cord, magnetic field inhomogeneity caused by the bone and cartilage in the spine, and motion of cerebrospinal
openaire   +2 more sources

Brain reward function in young people with cannabis use disorder: A functional magnetic resonance imaging study

Addiction, EarlyView.
Abstract Background and Aims Cannabis use disorder (CUD) affects ~50 million people globally. Neuroscientific theories suggest that a blunted neural response to non‐drug rewards is a hallmark of substance use disorders; however, this remains untested in CUD. The current study tested whether brain reward system responses to the anticipation and feedback
Martine Skumlien, Lisa‐Marie Greenwood, Arush Honnedevasthana Arun, Isabella Goodwin, Anastasia Paloubis, Tribikram Thapa Rana, Marianna Quinones Valera, Eugene McTavish, Gabrielle Abbott, Suraya Dunsford, Antonio Verdejo‐Garcia, Jessica Ramamurthy, Mark M. Schira, Nadia Solowij, Chao Suo, Valentina Lorenzetti   +15 more
wiley   +1 more source

Phase coupling between eye and brain pulsations is bidirectional and modulated by the parasympathetic system – An fMREye study

Acta Ophthalmologica, EarlyView.
Abstract Purpose Physiological pulsations driven by cardiac, respiratory, and vasomotor activity are essential for solute transport within perivascular and perineural cerebrospinal fluid (CSF) pathways that support brain and eye clearance systems. Previous studies have shown that parasympathetic blockade significantly reduces ocular pulsation power and
Ebrahimi Seyed‐Mohsen, Väyrynen Tommi, Huotari Niko, Saarela Ville, Honkamo Marja, Helakari Heta, Järvelä Matti, Korhonen Vesa, Raitamaa Lauri, Kiviniemi Vesa   +9 more
wiley   +1 more source

Safety pharmacology of acute mescaline administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Psychedelics, including mescaline, may serve as novel treatments for depression and anxiety. However, data is scarce on the safety of mescaline. Methods The present pooled analysis included two double‐blind, randomized, placebo‐controlled studies with a total of 48 participants and 96 mescaline administrations. Single oral‐dose administrations (n =
Aaron Klaiber, Mélusine Humbert‐Droz, Laura Ley, Yasmin Schmid, Matthias E. Liechti   +4 more
wiley   +1 more source

Regional-based static and dynamic alterations in Alzheimer disease: a longitudinal study

Arquivos de Neuro-Psiquiatria
Background Alzheimer disease (AD) leads to cognitive decline and alters functional connectivity (FC) in key brain regions. Resting-state functional magnetic resonance imaging (rs-fMRI) assesses these changes using static-FC for overall ...
Kuppe Channappa Usha, Honnenahally Ningappa Suma, Abhishek Appaji   +2 more
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Disentangling the effect of brain insulin resistance on brain health (BIR‐BrainHealth): Rationale and study protocol

Diabetic Medicine, EarlyView.
Abstract Aims Insulin signalling in the brain is crucial for systemic metabolic regulation and cognitive function. In some individuals, these effects are reduced, a phenomenon referred to as brain insulin resistance (BIR). This condition may contribute to the elevated risk of cognitive decline and dementia in diabetes, yet its prevalence, mechanisms ...
Sabrina Wangler, Peter Sørensen, Konni Kass, Nicole Jaqueline Jensen, Mark Bitsch Vestergaard, Julia Hummel, Ronja Völk, Julie Christine Antvorskov, Flemming Pociot, Jørgen Rungby, Martin Heni, Henrik Bo Wiberg Larsson   +11 more
wiley   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source