Results 41 to 50 of about 175,227 (263)

Real‐time estimation of dynamic functional connectivity networks

Human Brain Mapping, 2016
AbstractTwo novel and exciting avenues of neuroscientific research involve the study of task‐driven dynamic reconfigurations of functional connectivity networks and the study of functional connectivity in real‐time. While the former is a well‐established field within neuroscience and has received considerable attention in recent years, the latter ...
Monti, Ricardo Pio, Lorenz, Romy, Braga, Rodrigo M., Anagnostopoulos, Christoforos, Leech, Robert, Montana, Giovanni   +5 more
openaire   +7 more sources

Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer’s disease

Frontiers in Human Neuroscience, 2015
Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are the most common types of early-onset dementia. Here, we apply resting state functional magnetic resonance imaging (fMRI) to study functional brain connectivity ...
Anne eHafkemeijer, Anne eHafkemeijer, Anne eHafkemeijer, Christiane eMöller, Elise G P Dopper, Elise G P Dopper, Elise G P Dopper, Lize C Jiskoot, Lize C Jiskoot, Lize C Jiskoot, Tijn M Schouten, Tijn M Schouten, Tijn M Schouten, John C van Swieten, John C van Swieten, Wiesje M van der Flier, Wiesje M van der Flier, Hugo eVrenken, Hugo eVrenken, Yolande A L Pijnenburg, Frederik eBarkhof, Philip eScheltens, Jeroen evan der Grond, Serge A R B Rombouts, Serge A R B Rombouts, Serge A R B Rombouts   +25 more
doaj   +1 more source

Association between Functional Connectivity Hubs and Brain Networks [PDF]

Cerebral Cortex, 2011
Functional networks are usually accessed with "resting-state" functional magnetic resonance imaging using preselected "seeds" regions. Frequently, however, the selection of the seed locations is arbitrary. Recently, we proposed local functional connectivity density mapping (FCDM), an ultrafast data-driven to locate highly connected brain regions ...
Dardo, Tomasi, Nora D, Volkow
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Alzheimer Classification Using a Minimum Spanning Tree of High-Order Functional Network on fMRI Dataset

Frontiers in Neuroscience, 2017
Functional magnetic resonance imaging (fMRI) is one of the most useful methods to generate functional connectivity networks of the brain. However, conventional network generation methods ignore dynamic changes of functional connectivity between brain ...
Hao Guo, Hao Guo, Lei Liu, Junjie Chen, Yong Xu, Xiang Jie   +5 more
doaj   +1 more source

High-resolution network biology: connecting sequence with function [PDF]

Nature Reviews Genetics, 2013
Proteins are not monolithic entities; rather, they can contain multiple domains that mediate distinct interactions, and their functionality can be regulated through post-translational modifications at multiple distinct sites. Traditionally, network biology has ignored such properties of proteins and has instead examined either the physical interactions
Ryan, Colm J, Cimermančič, Peter, Szpiech, Zachary A, Sali, Andrej, Hernandez, Ryan D, Krogan, Nevan J   +5 more
openaire   +4 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Study of brain network alternations in non-lesional epilepsy patients by BOLD-fMRI

Frontiers in Neuroscience, 2023
ObjectiveTo investigate the changes of brain network in epilepsy patients without intracranial lesions under resting conditions.MethodsTwenty-six non-lesional epileptic patients and 42 normal controls were enrolled for BOLD-fMRI examination.
Zhisen Li, Xiaoxia Hou, Yanli Lu, Huimin Zhao, Meixia Wang, Bo Xu, Qianru Shi, Qian Gui, Guanhui Wu, Mingqiang Shen, Wei Zhu, Qinrong Xu, Xiaofeng Dong, Qingzhang Cheng, Jibin Zhang, Hongxuan Feng   +15 more
doaj   +1 more source

Alzheimer’s Disease Progressively Reduces Visual Functional Network Connectivity

Journal of Alzheimer's Disease Reports, 2021
Background: Postmortem studies of brains with Alzheimer’s disease (AD) not only find amyloid-beta (Aβ) and neurofibrillary tangles (NFT) in the visual cortex, but also reveal temporally sequential changes in AD pathology from higher-order association areas to lower-order areas and then primary visual area (V1) with disease progression.
Huang, Jie, Beach, Paul, Bozoki, Andrea, Zhu, David C.   +3 more
openaire   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source