Results 51 to 60 of about 175,227 (263)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Functional network connectivity alterations in schizophrenia and depression [PDF]

Psychiatry Research: Neuroimaging, 2017
There is a high degree of overlap between the symptoms of major depressive disorder (MDD) and schizophrenia, but it remains unclear whether the similar symptoms are derived from convergent alterations in functional network connectivity. In this study, we performed a group independent component analysis on resting-state functional MRI data from 20 MDD ...
Xing-Jie, Wu, Ling-Li, Zeng, Hui, Shen, Lin, Yuan, Jian, Qin, Peng, Zhang, Dewen, Hu   +6 more
openaire   +2 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Disparities in Connectivity Profiles Between Structural and Functional Networks in Patients With Temporal Lobe Epilepsy

Brain and Behavior
Temporal lobe epilepsy (TLE) is one of the most prevalent forms of epilepsy. Recent advancements in research have increasingly categorized TLE as a network disorder, focusing on its network characteristics. Prior studies predominantly examined changes in
Yu Zhou, Liangchao Du, Fangfang Xie, Dingyang Liu, Zhuanyi Yang, Chao Deng, Chunyao Zhou, Zhiquan Yang   +7 more
doaj   +1 more source

Examining the Role of Socioeconomic Status and Maternal Sensitivity in Predicting Functional Brain Network Connectivity in 5-Month-Old Infants

Frontiers in Neuroscience, 2022
Infancy is a sensitive period of human brain development that is plastically shaped by environmental factors. Both proximal factors, such as sensitive parenting, and distal factors, such as socioeconomic status (SES), are known predictors of individual ...
Johanna R. Chajes, Jessica A. Stern, Caroline M. Kelsey, Caroline M. Kelsey, Caroline M. Kelsey, Tobias Grossmann   +5 more
doaj   +1 more source

Inferring neuronal network functional connectivity with directed information [PDF]

Journal of Neurophysiology, 2017
This study brings together the techniques of voltage-sensitive dye recording and information theory to infer the functional connectome of the feeding central pattern generating network of Aplysia. In contrast to current statistical approaches, the inference method developed in this study is data driven and validated by conductance-based model circuits,
Zhiting, Cai, Curtis L, Neveu, Douglas A, Baxter, John H, Byrne, Behnaam, Aazhang   +4 more
openaire   +2 more sources

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

The Effect of Aging on Resting State Connectivity of Predefined Networks in the Brain

Frontiers in Aging Neuroscience, 2019
Recent studies have found a deleterious effect of age on a wide variety of measures of functional connectivity, and some hints at a relationship between connectivity at rest and cognitive functioning.
Eleanna Varangis, Christian G. Habeck, Qolamreza R. Razlighi, Yaakov Stern   +3 more
doaj   +1 more source

EEG Signatures of Dynamic Functional Network Connectivity States [PDF]

Brain Topography, 2017
The human brain operates by dynamically modulating different neural populations to enable goal directed behavior. The synchrony or lack thereof between different brain regions is thought to correspond to observed functional connectivity dynamics in resting state brain imaging data.
E A, Allen, E, Damaraju, T, Eichele, L, Wu, V D, Calhoun   +4 more
openaire   +2 more sources

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source